BMC Surgery | |
Outcomes and cost analysis of laparoscopic versus open appendectomy for treatment of acute appendicitis: 4-years experience in a district hospital | |
Vincenzo Antonacci1  Goffredo Arena3  Manuel Arena2  Biagio Di Stefano2  Alessio Licciardello2  Vincenzo Minutolo2  | |
[1] Division of General Surgery, Civil Hospital of Ragusa, Piazza Caduti di Nassiryia 1, 97100 Ragusa, Italy;Department of Surgical Sciences, Organ Transplantation and Advanced Technologies, University of Catania, via Santa Sofia 84, 95123 Catania, Italy;Department of Surgery, McGill University, 687 Pine Avenue, Montreal, QC H3A1A1, Canada | |
关键词: Length of hospital stay; Operative time; Intra-abdominal abscess; Complications; Costs; Open appendectomy; Laparoscopic appendectomy; | |
Others : 866872 DOI : 10.1186/1471-2482-14-14 |
|
received in 2013-12-16, accepted in 2014-03-13, 发布年份 2014 | |
【 摘 要 】
Background
Laparoscopic appendectomy is not yet unanimously considered the “gold standard” in the treatment of acute appendicitis because of its higher operative time, intra-abdominal abscess risk, and costs compared to open appendectomy. This study aimed to compare outcomes and cost of laparoscopic and open appendectomy in a district hospital.
Methods
A retrospective analysis of 230 patients who underwent appendectomy at the Division of General Surgery of the Civil Hospital of Ragusa, Italy, from May 2008 to May 2012 was performed. The variables analyzed included patients data (age, gender, previous abdominal surgery, preoperative WBC count, duration of symptoms, ASA risk score), rate of uncomplicated or complicated appendicitis, operative time, postoperative complications, length of hospital stay, and total costs. The patients were divided in two groups according to the surgical approach and compared for each variable. The results were analyzed using the t Student test for quantitative variables, and the Chi-square test with Yates correction and Fisher exact test for categorical.
Results
Laparoscopic appendectomy was performed in 139 patients, open appendectomy in 91. Two cases (1.4%) were converted to open procedure and included in the laparoscopic group data. Patient data and rate of complicated appendicitis were similar in the two study groups. There was no statistical difference (p = 0.476) in the mean operative time between the laparoscopic (52.2 min; range, 20–155) and open appendectomy (49.3 min; range, 20–110) groups. The overall incidence of minor and major complications was significantly lower (p = 0.006) after laparoscopic appendectomy (2.9%, 4 cases) than after open appendectomy (13.2%, 12 cases); rate of intra-abdominal abscess were similar. The length of hospital stay was significantly shorter (p = 0.001) in laparoscopic group (2.75 days; range, 1–8) than in open group (3.87 days; range, 1–19). The mean total cost was 2282 Euro in laparoscopic group and 2337 Euro in open group, with a no significant difference of 55 Euro (p = 0.812).
Conclusion
Laparoscopic appendectomy is associated with fewer complications, shorter hospital stay, and similar operative time, intra-abdominal abscess rate, and total costs, compared with open appendectomy. Therefore, laparoscopic appendectomy can be recommended as preferred approach in acute appendicitis.
【 授权许可】
2014 Minutolo et al.; licensee BioMed Central Ltd.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
20140728062804269.pdf | 174KB | download |
【 参考文献 】
- [1]Semm K: Endoscopic appendectomy. Endoscopy 1983, 15:59-64.
- [2]McGrath B, Buckius MT, Grim R, Bell T, Ahuja V: Economics of appendicitis: cost trend analysis of laparoscopic versus open appendectomy from 1998 to 2008. J Surg Res 2011, 171:e161-e168.
- [3]Ortega AE, Hunter JG, Peters JH, Swanstrom LL, Schirmer B: A prospective, randomized comparison of laparoscopic appendectomy with open appendectomy. Laparoscopic Appendectomy Study Group. Am J Surg 1995, 169:208-212.
- [4]Fingerhut A, Millat B, Borrie F: Laparoscopic versus open appendectomy: time to decide. World J Surg 1999, 1999(23):835-845.
- [5]Minutolo V, Gagliano G, Minutolo O, Carnazza M, La Terra S, Buttafuoco A, Dipietro S, Lanteri R: Laparoscopic appendectomy for acute appendicitis. Chir Ital 2009, 61:591-596.
- [6]Milewczyk M, Michalik M, Ciesielski M: A prospective, randomized, unicenter study comparing laparoscopic and open treatments of acute appendicitis. Surg Endosc 2003, 17:1023-1028.
- [7]Pedersen AG, Petersen OB, Wara P, Rønning H, Qvist N, Laurberg S: Randomized clinical trial of laparoscopic versus open appendicectomy. Br J Surg 2001, 88:200-205.
- [8]Sauerland S, Lefering R, Neugebauer EA: Laparoscopic versus open surgery for suspected appendicitis. Cochrane Database Syst Rev 2010, 10:CD001546.
- [9]Wei B, Qi CL, Chen TF, Zheng ZH, Huang JL, Hu BG, Wei HB: Laparoscopic versus open appendectomy for acute appendicitis: a metaanalysis. Surg Endosc 2011, 25:1199-1208.
- [10]Krisher SL, Browne A, Dibbins A, Tkacz N, Curci M: Intraabdominal abscess after laparoscopic appendectomy for perforated appendicitis. Arch Surg 2001, 136:438-441.
- [11]Loh A, Taylor RS: Laparoscopic appendectomy. Br J Surg 1992, 27:289-290.
- [12]Schreiber JH: Early experience with laparoscopic appendectomy in women. Surg Endosc 1987, 1:211-216.
- [13]Laine S, Rantala A, Gullichsen R, Ovaska J: Laparoscopic appendectomy: is it worthwhile? A prospective, randomized study in young women. Surg Endosc 1997, 11:95-97.
- [14]Varela JE, Hinojosa MW, Nguyen NT: Laparoscopy should be the approach of choice for acute appendicitis in morbidly obese. Am J Surg 2008, 196:218-222.
- [15]Jaffer U, Cameron AE: Laparoscopic appendectomy: a junior trainee’s learning curve. JSLS 2008, 12:288-291.
- [16]Nakhamiyayev V, Galldin L, Chiarello M, Lumba A, Gorecki PJ: Laparoscopic appendectomy is the preferred approach for appendicitis: a retrospective review of two practice patterns. Surg Endosc 2010, 24:859-864.
- [17]Bennett J, Boddy A, Rhodes M: Choice of approach for appendicectomy: a meta-analysis of open versus laparoscopic appendicectomy. Surg Laparosc Endosc Percutan Tech 2007, 17:245-255.
- [18]Li X, Zhang J, Sang L, Zhang W, Chu Z, Li X, Liu Y: Laparoscopic versus conventional appendectomy - a meta-analysis of randomized controlled trials. BMC Gastroenterol 2010, 10:129. BioMed Central Full Text
- [19]Sauerland S, Lefering R, Neugebauer E: Laparoscopic versus open surgery for suspected appendicitis (review). Cochrane Database Syst Rev 2004, 4:CD001546.
- [20]Gupta R, Sample C, Bamehriz F, Birch DW: Infectious complications following laparoscopic appendectomy. Can J Surg 2006, 49:397-400.
- [21]Katkhouda N, Friedlander MH, Grant SW, Achanta KK, Essani R, Paik P, Velmahos G, Campos G, Mason R, Mavor E: Intraabdominal abscess rate after laparoscopic appendectomy. Am J Surg 2000, 180:456-461.
- [22]Cueto J, D’Allemagne B, Vázquez-Frias JA, Gomez S, Delgado F, Trullenque L, Fajardo R, Valencia S, Poggi L, Ballì J, Diaz J, González R, Mansur JH, Franklin ME: Morbidity of laparoscopic surgery for complicated appendicitis: an international study. Surg Endosc 2006, 20:717-720.
- [23]Vernon AH, Georgeson KE, Harmon CM: Pediatric laparoscopic appendectomy for acute appendicitis. Surg Endosc 2004, 18:75-79.
- [24]Lintula H, Kokki H, Vanamo K: Single blind randomized clinical trial of laparoscopic versus open appendicectomy in children. Br J Surg 2001, 88:510-514.
- [25]Kurtz RJ, Heimann TM: Comparison of open and laparoscopic treatment of acute appendicitis. Am J Surg 2001, 182:211-214.
- [26]Martin LC, Puente I, Sosa JL, Bassin A, Breslaw R, McKenney MG, Ginzburg E, Sleeman D: Open versus laparoscopic appendectomy: a prespective randomized comparison. Ann Surg 1995, 222:256-262.
- [27]Hansen JB, Smithers BM, Schache D, Wall DR, Miller BJ, Menzies BL: Laparoscopic versus open appendectomy: prospective randomized trial. Wolrd J Surg 1996, 20:17-21.
- [28]Williams MD, Collins JN, Wright TF, Fenoglio ME: Laparoscopic versus open appendectomy. South Med J 1996, 89:668-674.
- [29]Macarulla E, Vallet J, Abad JM, Hussein H, Fernandez E, Nieto B: Laparoscopic versus open appendectomy: a prospective randomized trial. Surg Laparosc Endosc 1997, 7:335-339.
- [30]Minné L, Varner D, Burnell A, Ratzer E, Clark J, Haun W: Laparoscopic versus open appendectomy: a prospective randomized study of outcomes. Arch Surg 1997, 132:708-711.
- [31]Heikkinen TJ, Haukipuro K, Hulkko A: Cost-effective appendectomy: open or laparoscopic? A prospective randomized study. Surg Endosc 1998, 12:1204-1208.
- [32]Long KH, Bannon MP, Zietlow SP, Helgeson ER, Harmsen WS, Smith CD, Ilstrup DM, Baerga-Varela Y, Sarr MG, Laparoscopic Appendectomy Interest Group: A prospective randomized comparison of laparoscopic appendectomy with open appendectomy: clinical and economic analyses. Surgery 2001, 129:390-400.
- [33]Wei HB, Huang JL, Zheng ZH, Wei B, Zheng F, Qiu WS, Guo WP, Chen TF, Wang TB: Laparoscopic versus open appendectomy: a prospective randomized comparison. Surg Endosc 2010, 24:266-269.