Physical activity, sedentary behaviors, and estimated insulin sensitivity and secretion in pregnant and non-pregnant women

BMC Pregnancy and Childbirth

Paul W Franks⁶  Ingrid Mogren⁷  Steven E Kahn³  Magnus Domellöf⁹  Les Bluck⁸  Antony Wright⁸  Margareta Persson¹  Susanne Steiginga⁵  Frida Renström⁶  Jeremy Pomeroy⁴  Anna Gradmark² 

[1] Department of Clinical Science and Department of Nursing, Umeå University Hospital, Umeå, Sweden;Genetic Epidemiology and Clinical Research Group, Department of Public Health and Clinical Medicine, Section for Medicine, Umeå University Hospital, Umeå, Sweden;Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, WA, USA;Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University, Malmö, Sweden;Free University Medical Center, Amsterdam, the Netherlands;Department of Nutrition, Harvard School of Public Health, Boston, MA, USA;Department of Clinical Sciences, Obstetrics & Gynecology, Umeå University Hospital, Umeå, Sweden;MRC Human Nutrition Research, Cambridge, UK;Department of Pediatrics, Umeå University Hospital, Umeå, Sweden

关键词: insulin sensitivity;    β-cell response;    sedentary time;    physical activity;    pregnancy;   

Others  :  1164310
DOI  :  10.1186/1471-2393-11-44

 received in 2011-02-18, accepted in 2011-06-16,  发布年份 2011

【 摘 要 】

Background

Overweight and obesity during pregnancy raise the risk of gestational diabetes and birth complications. Lifestyle factors like physical activity may decrease these risks through beneficial effects on glucose homeostasis. Here we examined physical activity patterns and their relationships with measures of glucose homeostasis in late pregnancy compared to non-pregnant women.

Methods

Normal weight and overweight women without diabetes (N = 108; aged 25-35 years) were studied; 35 were pregnant (in gestational weeks 28-32) and 73 were non-pregnant.

Insulin sensitivity and β-cell response were estimated from an oral glucose tolerance test. Physical activity was measured during 10-days of free-living using a combined heart rate sensor and accelerometer. Total (TEE), resting (REE), and physical activity (PAEE) energy expenditure were measured using doubly-labeled water and expired gas indirect calorimetry.

Results

Total activity was associated with reduced first-phase insulin response in both pregnant (Regression r² = 0.11; Spearman r = -0.47; p = 0.007) and non-pregnant women (Regression r² = 0.11 Spearman; r = -0.36; p = 0.002). Relative to non-pregnant women, pregnant women were estimated to have secreted 67% more insulin and had 10% lower fasting glucose than non-pregnant women. Pregnant women spent 13% more time sedentary, 71% less time in moderate-to-vigorous intensity activity, had 44% lower objectively measured total activity, and 12% lower PAEE than non-pregnant women. Correlations did not differ significantly for any comparison between physical activity subcomponents and measures of insulin sensitivity or secretion.

Conclusions

Our findings suggest that physical activity conveys similar benefits on glucose homeostasis in pregnant and non-pregnant women, despite differences in subcomponents of physical activity.

【 授权许可】

   
2011 Gradmark et al; licensee BioMed Central Ltd.

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