Is there a role for monocyte chemoattractant protein-1 in delirium? Novel observations in elderly hip fracture patients

BMC Research Notes

Vibeke Juliebø²  Ingebjørg Seljeflot²  Leiv Otto Watne¹  Torgeir Bruun Wyller¹  Kjersti Skrede¹ 

[1] Faculty of Medicine, University of Oslo, Oslo, Norway;Department of Cardiology, Oslo University Hospital, Oslo, Norway

关键词: Hip fracture;    Inflammation;    Cytokines;    Delirium;   

Others  :  1232480
DOI  :  10.1186/s13104-015-1129-5

 received in 2014-09-15, accepted in 2015-04-21,  发布年份 2015

【 摘 要 】

Background

Delirium is common, associated with poor outcome, but its pathophysiology remains obscure. The aim of the present study was to study a possible role of monocyte chemoattractant protein-1 (MCP-1) in the development of delirium.

Findings

A prospective cohort of 19 hip fracture patients (median age 83 years) were screened for delirium daily by validated methods. MCP-1 was measured on arrival and postoperatively. The number of patients with a raise in MCP-1 was statistically significantly higher in the group with delirium in the postoperative phase compared to the no-delirium group (5/6 vs. 1/7, p = .03).

Conclusions

MCP-1 might play a role in the development of delirium.

【 授权许可】

   
2015 Skrede et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

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