Malignant transformation in 5071 southern Taiwanese patients with potentially malignant oral mucosal disorders

BMC Oral Health

Chung-Ho Chen²  Yuk-Kwan Chen⁴  Yu-Hsun Kao¹  Ching-Yi Chen⁶  Wen-Chen Wang²  Yen-Hsuan Tail⁵  Yen-Yun Wang³ 

[1] Department of Clinical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;Instrument Technology Research Center, National Applied Research Laboratories, Hsinchu City 300, Taiwan;Oral & Maxillofacial Imaging Center, Kaohsiung Medical University, Kaohsiung, Taiwan;Division of Oral and Maxillofacial Surgery, Department of Dentistry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;Division of Oral Pathology and Maxillofacial Radiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

关键词: Oral squamous cell carcinoma;    Oral epithelial dysplasia;    Malignant transformation;    Oral potentially malignant disorders;   

Others  :  1109583
DOI  :  10.1186/1472-6831-14-99

 received in 2014-04-08, accepted in 2014-07-23,  发布年份 2014

【 摘 要 】

Background

Oral cancers can be preceded by clinically evident oral potentially malignant disorders (OPMDs). The current study evaluated the rate and the time of malignant transformation in the various OPMDs in a cohort of patients from southern Taiwan. Parameters possibly indicative for malignant transformation of OPMDs, such as epidemiological and etiological factors, and clinical and histopathological features were also described.

Methods

We followed-up 5071 patients with OPMDs—epithelial dysplasia with oral submucous fibrosis, epithelial dysplasia with hyperkeratosis/epithelial hyperplasia, hyperkeratosis/epithelial hyperplasia, oral submucous fibrosis, lichen planus, and verrucous hyperplasia—between 2001 and 2010 for malignant transformation.

Results

Two hundred nineteen of these 5071 OPMD patients (202 men, 17 women; mean age: 51.25 years; range: 30–81 years) developed oral cancers (179 squamous cell carcinomas; 40 verrucous carcinomas) in the same sites as the initial lesions at least 6 months after their initial biopsies. The overall transformation rate was 4.32% (mean duration of transformation: 33.56 months; range: 6–67 months). Additionally, the mean time of malignant transformation was significantly shorter for lesions with than without epithelial dysplasia. The risk of malignant transformation was 1.89 times higher for epithelially dysplastic than non-dysplastic lesions. The anatomical site of OPMD and the presence of epithelial dysplasia were significantly associated with malignant transformation. The hazard rate ratio was 1.87 times larger for tongue lesions than for buccal lesions.

Conclusion

Patients with OPMDs require long-term follow up.

【 授权许可】

   
2014 Wang et al.; licensee BioMed Central Ltd.

【 图 表 】

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