Quality of life is associated with physical activity and fitness in cystic fibrosis

BMC Pulmonary Medicine

Susi Kriemler⁴  Hans-Georg Posselt³  Christian Schindler¹  Thomas Schenk²  Alexandra Hebestreit⁸  Kristina Roth⁸  Manfred Ballmann⁶  Sibylle Junge⁵  Stephanie Kieser⁸  Kerstin Schmid⁸  Helge Hebestreit⁷ 

[1] Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland;Department of Anaesthesiology, University of Würzburg, Würzburg, Germany;Pediatric Department, Johann Wolfgang Goethe University, Frankfurt, Germany;Institute for Social and Preventive Medicine, University of Zürich, Zürich, Switzerland;Pediatric Pulmonology and Neonatology, Hannover Medical School, Hannover, Germany;St Josef Hospital Pediatric Clinic, Ruhr University Bochum, Bochum, Germany;Universitäts-Kinderklinik, Josef-Schneider-Str. 2, 97080 Würzburg, Germany;Pediatric Department, University of Würzburg, Würzburg, Germany

关键词: Questionnaire;    Accelerometry;    Longitudinal analysis;    Oxygen uptake;    Exercise testing;   

Others  :  865423
DOI  :  10.1186/1471-2466-14-26

 received in 2013-06-03, accepted in 2014-02-19,  发布年份 2014

【 摘 要 】

Background

Health-related and disease-specific quality of life (HRQoL) has been increasingly valued as relevant clinical parameter in cystic fibrosis (CF) clinical care and clinical trials. HRQoL measures should assess – among other domains – daily functioning from a patient’s perspective. However, validation studies for the most frequently used HRQoL questionnaire in CF, the Cystic Fibrosis Questionnaire (CFQ), have not included measures of physical activity or fitness. The objective of this study was, therefore, to determine the cross-sectional and longitudinal relationships between HRQoL, physical activity and fitness in patients with CF.

Methods

Baseline (n = 76) and 6-month follow-up data (n = 70) from patients with CF (age ≥12 years, FEV1 ≥35%) were analysed. Patients participated in two multi-centre exercise intervention studies with identical assessment methodology. Outcome variables included HRQoL (German revised multi-dimensional disease-specific CFQ (CFQ-R)), body composition, pulmonary function, physical activity, short-term muscle power, and aerobic fitness by peak oxygen uptake and aerobic power.

Results

Peak oxygen uptake was positively related to 7 of 13 HRQoL scales cross-sectionally (r = 0.30-0.46). Muscle power (r = 0.25-0.32) and peak aerobic power (r = 0.24-0.35) were positively related to 4 scales each, and reported physical activity to 1 scale (r = 0.29). Changes in HRQoL-scores were directly and significantly related to changes in reported activity (r = 0.35-0.39), peak aerobic power (r = 0.31-0.34), and peak oxygen uptake (r = 0.26-0.37) in 3 scales each. Established associates of HRQoL such as FEV1 or body mass index correlated positively with fewer scales (all 0.24 < r < 0.55).

Conclusions

HRQoL was associated with physical fitness, especially aerobic fitness, and to a lesser extent with reported physical activity. These findings underline the importance of physical fitness for HRQoL in CF and provide an additional rationale for exercise testing in this population.

Trial registration

ClinicalTrials.gov, NCT00231686

【 授权许可】

   
2014 Hebestreit et al.; licensee BioMed Central Ltd.

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