New adipokines vaspin and omentin. Circulating levels and gene expression in adipose tissue from morbidly obese women

BMC Medical Genetics

Cristóbal Richart¹  Daniel del Castillo⁵  Fátima Sabench⁵  Mercè Hernandez⁵  José Antonio Porras³  Montserrat Olona²  Carmen Aguilar¹  Montserrat Broch¹  Anna Crescenti³  Ximena Terra¹  Beatriz Morancho³  David Riesco⁴  Yunuen Quintero¹  Teresa Auguet¹ 

[1] Grup d'estudi de Malalties Metabòliques associades a insulin resistència (GEMMAIR) 2010PFR-URV-B2-14 and 2009 SGR 95 (AGAUR;Servei Epidemiologia i estadística, Hospital Universitari Joan XXIII Tarrogona, Tarragona, Spain;Grup de Recerca en Medicina Aplicada Hospital Joan XXIII. Departament de Medicina i Cirurgia. Universitat Rovira i Virgili (URV), IISPV, Tarragona, Spain;Servei Medicina Interna. Hospital Universitari Joan XXIII Tarragona, Tarragona, Spain;Servei de Cirurgia. Hospital Sant Joan de Reus, Tarragona, Spain. Departament de Medicina i Cirurgia. Universitat Rovira i Virgili (URV), IISPV, Tarragona, Spain

关键词: vaspin;    omentin;    mRNA tissue expression;    morbid obesity;    circulating levels;   

Others  :  1178050
DOI  :  10.1186/1471-2350-12-60

 received in 2011-01-19, accepted in 2011-04-28,  发布年份 2011

【 摘 要 】

Background

Vaspin and omentin are recently described molecules that belong to the adipokine family and seem to be related to metabolic risk factors. The objectives of this study were twofold: to evaluate vaspin and omentin circulating levels and mRNA expression in subcutaneous and visceral adipose tissues in non-diabetic morbidly obese women; and to assess the relationship of vaspin and omentin with anthropometric and metabolic parameters, and other adipo/cytokines.

Design

We analysed vaspin and omentin circulating levels in 71 women of European descent (40 morbidly obese [BMI ≥ 40 kg/m²] and 31 lean [BMI ≤ 25]). We assessed vaspin and omentin gene expression in paired samples of visceral and subcutaneous abdominal adipose tissue from 46 women: 40 morbidly obese and 6 lean. We determined serum vaspin and plasma omentin levels with an Enzyme-Linked Immunosorbent Assay and adipose tissue mRNA expression by real time RT-PCR.

Results

Serum vaspin levels in the morbidly obese were not significantly different from those in controls. They correlated inversely with levels of lipocalin 2 and interleukin 6. Vaspin mRNA expression was significantly higher in the morbidly obese, in both subcutaneous and visceral adipose tissue.

Plasma omentin levels were significantly lower in the morbidly obese and they correlated inversely with glucidic metabolism parameters. Omentin circulating levels, then, correlated inversely with the metabolic syndrome (MS). Omentin expression in visceral adipose tissue was significantly lower in morbidly obese women than in controls.

Conclusions

The present study indicates that vaspin may have a compensatory role in the underlying inflammation of obesity. Decreased omentin circulating levels have a close association with MS in morbidly obese women.

【 授权许可】

   
2011 Auguet et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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