Genetic association between selected cytokine genes and glioblastoma in the Han Chinese population

BMC Cancer

Tianbo Jin¹  Xiaolan Li¹  Jiayi Zhang¹  Hong Wang¹  Tingting Geng¹  Gang Li²  Guodong Gao²  Chao Chen³ 

[1] National Engineering Research Center for Miniaturized Detection Systems, Xi’an 710069, China

[2] Department of Neurosurgery, Tangdu hospital, the Fourth Military Medical University, Xi’an 710038, China

[3] Mailbox 386, #229 North Taibai Road, Xi’an 710069, Shaanxi, China

关键词: Case–control study;    Tag single nucleotide polymorphism (tSNP);    Glioblastoma (GBM);    Cytokine gene;   

Others  :  1079755
DOI  :  10.1186/1471-2407-13-236

 received in 2012-12-01, accepted in 2013-05-08,  发布年份 2013

【 摘 要 】

Background

Glioblastoma (GBM) is the most malignant brain tumor. Many abnormal secretion and expression of cytokines have been found in GBM, initially speculated that the occurrence of GBM may be involved in these abnormal secretion of cytokines. This study aims to detect the association of cytokine genes with GBM.

Methods

We selected seven tag single nucleotide polymorphisms (tSNPs) in six cytokine genes, which previously reported to be associated with brain tumors, and analyzed their association with GBM in a Han Chinese population using χ² test and genetic model analysis.

Results

We found two risk tSNPs and one protective tSNP. By χ² test, the rs1801275 in IL-4R showed an increased risk of GBM. In the genetic model analysis, the genotype “TC” of rs20541 in IL-13 gene showed an increased risk of GBM in over-dominant model (OR = 2.00; 95% CI, 1.13-3.54, p = 0.015); the genotype “CT” of rs1800871 in the IL-10 gene showed a decrease risk in the over-dominant model (OR = 0.57; 95% CI, 0.33 – 0.97; p = 0.037). The genotype “AG” of rs1801275 in the IL-4R gene showed an increase risk in over-dominant model (OR = 2.29; 95% CI, 1.20 - 4.35; p = 0.0081) We further analyzed whether the six cytokine genes have a different effect on the disease in gender specific population, and found that the allele “G” of rs2243248 in the IL-4 gene showed a decrease risk of GBM in female (OR = 0.35, 95% CI, 0.13 - 0.94, p = 0.0032), but the allele “T” showed a decrease risk in male (OR = 0.30, 95% CI, 0.17 - 0.53, p = 0.0032).

Conclusions

Our findings, combined with previously reported results, suggest that cytokine genes have potential role in GBM development, which may be useful to early prognostics for GBM in the Han Chinese population.

【 授权许可】

   
2013 Jin et al.; licensee BioMed Central Ltd.

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