Epigenetic signature of birth weight discordance in adult twins

BMC Genomics

Lene Christiansen¹  Kaare Christensen³  Elmar W Tobi²  Jacob von Bornemann Hjelmborg¹  Bastiaan T Heijmans²  Morten Frost⁴  Qihua Tan³ 

[1] Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, J. B. Winsløws Vej 9B, DK-5000 Odense C, Denmark;Departments of Molecular Epidemiology and Medical Statistics, Leiden University Medical Center, Odense, Leiden, The Netherlands;Department of Clinical Genetics, Odense University Hospital, Odense, Denmark;Department of Endocrinology, Odense University Hospital, Odense, Denmark

关键词: DNA methylation;    Birth weight discordance;    Identical twins;   

Others  :  1089843
DOI  :  10.1186/1471-2164-15-1062

 received in 2014-06-25, accepted in 2014-11-20,  发布年份 2014

【 摘 要 】

Background

A low birth weight has been extensively related to poor adult health outcomes. Birth weight can be seen as a proxy for environmental conditions during prenatal development. Identical twin pairs discordant for birth weight provide an extraordinary model for investigating the association between birth weight and adult life health while controlling for not only genetics but also postnatal rearing environment. We performed an epigenome-wide profiling on blood samples from 150 pairs of adult monozygotic twins discordant for birth weight to look for molecular evidence of epigenetic signatures in association with birth weight discordance.

Results

Our association analysis revealed no CpG site with genome-wide statistical significance (FDR < 0.05) for either qualitative (larger or smaller) or quantitative discordance in birth weight. Even with selected samples of extremely birth weight discordant twin pairs, no significant site was found except for 3 CpGs that displayed age-dependent intra-pair differential methylation with FDRs 0.014 (cg26856578, p = 3.42e-08), 0.0256 (cg15122603, p = 1.25e-07) and 0.0258 (cg16636641, p = 2.05e-07). Among the three sites, intra-pair differential methylation increased with age for cg26856578 but decreased with age for cg15122603 and cg16636641. There was no genome-wide statistical significance for sex-dependent effects on intra-pair differential methylation in either the whole samples or the extremely discordant twins.

Conclusions

Genome-wide DNA methylation profiling did not reveal epigenetic signatures of birth weight discordance although some sites displayed age-dependent intra-pair differential methylation in the extremely discordant twin pairs.

【 授权许可】

   
2014 Tan et al.; licensee BioMed Central Ltd.

【 图 表 】

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