Association of cardiovascular response to an acute resistance training session with the ACE gene polymorphism in sedentary women: a randomized trial

BMC Cardiovascular Disorders

Carmen Silvia Grubert Campbell²  Jonato Prestes²  Margô G O Karnikowski⁴  Vinícius Carolino de Souza²  Nuno Manuel Frade de Sousa³  Ramires Alsamir Tibana²  Jéssica Cardoso de Souza¹ 

[1] Physical Education Program, Catholic University of Brasilia, Q.S. 07, Lote 01, EPTC – Bloco G. Zip code: 71966-700 – Aguas Claras – Federal District, Brasilia, Brazil;Graduation Program on Physical Education, Catholic University of Brasilia, Brasilia, Brazil;Graduation Program Inter-unities - Bioengineering, EESC/FMRP/IQSC, USP, Sao Carlos, Brazil;Graduation Program in Medical Sciences, University of Brasilia, Brasilia, Brazil

关键词: Angiotensin converting enzyme;    Polymorphism;    Heart rate;    Blood pressure;    Resistance training;   

Others  :  857901
DOI  :  10.1186/1471-2261-13-3

 received in 2012-06-13, accepted in 2012-12-27,  发布年份 2013

【 摘 要 】

Background

The aim of the present study was to verify the effects of an acute resistance training (RT) session and insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) on systolic (SBP), diastolic (DBP) and mean blood pressure (MBP), and heart rate (HR).

Methods

The sample consisted of 27 sedentary women (33.3 ± 8.2 yrs; 69.1 ± 13.8 kg; 1.57 ± 0.05 m; 27.6 ± 5.1 kg/m²) divided into two groups according to their polymorphism I/D (DD = 9; II + ID = 18). Volunteers underwent two experimental sessions: RT – an acute session performed with three sets at 60% of one-repetition maximum (1RM) interspersed with 1 minute rest interval between exercises and sets, and a control session (CON) in which they remained seated for 30 minutes in the laboratory. SBP, DBP, MBP and HR were measured before exercise and during one hour every 10 minutes after sessions, in the seated position. A two-way ANOVA for repeated measures with Tukey’s post hoc test was used for the intra and inter-group comparisons.

Results

There were no statistically significant differences on SBP, DBP and MBP after the experimental protocols, and no effect of ACE polymorphism (P > 0.05). However, comparing CON versus exercise effect size values (ES), homozygotic carriers of the allele D presented a drop in SBP which was considered moderate, while in allele I carriers it was small, 30 minutes after exercise. In MBP, homozygotic D carriers exhibited a large ES 20 minutes post-exercise. HR was higher at 10, 20 and 30 minutes after exercise as compared to pre-exercise only for carriers of the I allele (P < 0.05).

Conclusions

Therefore, an acute RT session reduces clinical BP. In addition to this; it seems that ACE polymorphism had some influence on cardiovascular response to exercise.

Trial Registration

RBR-6GDYVZ

【 授权许可】

   
2013 Souza et al.; licensee BioMed Central Ltd.

【 图 表 】

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