Assessment of quality of life in people with severe and enduring anorexia nervosa: a comparison of generic and specific instruments

BMC Psychiatry

Stephen Touyz¹  Shameran Slewa-Younan³  Jonathan Mond⁶  Hubert Lacey⁴  Daniel Le Grange²  Ross Crosby⁷  Scott Engel⁷  Phillipa Hay⁵  Deborah Mitchison³ 

[1] School of Psychology, University of Sydney, Sydney, Australia;Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, United States of America;School of Medicine, University of Western Sydney, Sydney, Australia;Division of Population Health Sciences and Education, Eating Disorders Research Team, St George’s, University of London, London, United Kingdom;School of Medicine, James Cook University, Townsville, Australia;School of Sociology, Australian National University, Canberra, Australia;School of Medicine and Health Sciences, University of North Dakota, Grand Forks, United States of America

关键词: Treatment;    Burden;    Measurement;    Eating disorder;    Psychometric;    Questionnaires;    Anorexia nervosa;    Quality of life;   

Others  :  1123911
DOI  :  10.1186/1471-244X-13-284

 received in 2013-01-29, accepted in 2013-06-21,  发布年份 2013

【 摘 要 】

Background

Criticisms that generic measures of health-related quality of life (HRQoL) are not sensitive to impairment in anorexia nervosa (AN) has spurred the development of disease-specific measures. This study aimed to compare the psychometric properties of a generic to a disease-specific measure of HRQoL.

Methods

63 participants with AN completed measures of a generic HRQoL (SF-12), disease-specific HRQoL (Eating Disorders Quality of Life Questionnaire; EDQOL), functional impairment (days out of role; DOR; Work and Social Adjustment Scale; WSAS), and eating disorder severity (Eating Disorder Examination; EDE) at baseline, post-treatment, and 6- and 12-months follow-up. Cronbach’s α was computed for the SF-12 and EDQOL (internal consistency). Correlations were assessed between SF-12/EDQOL scores and DOR, WSAS, and EDE scores (convergence validity). Three sets of three multiple linear regressions were performed using SF-12 and EDQOL scores as predictors and change in DOR, WSAS, and EDE global scores from baseline to (i) post-treatment, (ii) 6-month follow-up, (iii) and 12-month follow-up as dependent variables (predictive validity and sensitivity).

Results

The EDQOL displayed stronger internal consistency (α = 0.92) than the SF-12 (α = 0.80). The SF-12 converged more strongly with DOR and the WSAS (r_p = −0.31 to −0.63 vs. 0.06 to 0.70), while the EDQOL converged more strongly with the EDE (r_p = −0.01 to 0.48 vs. -0.01 to −0.37). The SF-12 demonstrated stronger predictive validity (β = −0.55 to 0.29) and sensitivity to changes in ED severity (β = −0.47 to 0.32).

Conclusions

The SF-12 is a valid and sensitive measure of HRQoL impairment in patients with AN. While the SF-12 may be preferred in research comparing EDs to other populations, and in research and practice as an indicator of functional impairment; the EDQOL may be preferred by clinicians and researchers interested in HRQoL impairment specifically associated with an ED and as an additional indicator of ED severity.

【 授权许可】

   
2013 Mitchison et al.; licensee BioMed Central Ltd.

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