The development of TH2 responses from infancy to 4 years of age and atopic sensitization in areas endemic for helminth infections

Allergy, Asthma & Clinical Immunology

Yenny Djuardi³  Taniawati Supali¹  Heri Wibowo¹  Yvonne CM Kruize³  Serge A Versteeg²  Ronald van Ree²  Erliyani Sartono³  Maria Yazdanbakhsh³ 

[1] Department of Parasitology, Faculty of Medicine, University of Indonesia, Salemba 6, Jakarta 10430, Indonesia

[2] Department of Experimental Immunology and Department of Otorhinolaryngology, Academic Medical Center, Amsterdam University, Amsterdam, The Netherlands

[3] Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands

关键词: Children;    Skin prick test;    Atopy;    Helminth;    IL-5;    IgE;    TH₂;   

Others  :  792341
DOI  :  10.1186/1710-1492-9-13

 received in 2012-11-13, accepted in 2013-03-01,  发布年份 2013

【 摘 要 】

Background

Helminth infections and allergies are associated with TH₂ responses. Whereas the development of TH₂ responses and allergic disorders in pediatric populations has been examined in affluent countries, no or little data exist from low income regions of the world.

The aim of this study is to examine factors influencing the development of TH₂ responses of children born in areas endemic for helminth infections and to relate these factors to atopic sensitization at 4 years of age.

Methods

Data were collected from pregnant mothers on helminth infections, education and socioeconomic status (SES). Total IgE, IL-5 in response to mitogen, and helminth antigens were measured in children at 2, 5, 12, 24 and 48 months of age. Skin prick testing (SPT) and allergen-specific IgE were determined at 4 years of age.

Results

Strong TH₂ responses were seen at 5 months of age and increased with time. Although maternal filarial infection was associated with helminth-antigen specific TH₂ responses, it was low maternal education or SES but not helminth infection, which was associated with the development of high total IgE and PHA-induced IL-5. At 4 years of age when allergen reactivity was assessed by SPT, the high general TH₂ responses did not translate into higher prevalence of SPT. The risk factor for SPT reactivity was low maternal education which decreased the risk of SPT positivity to allergens (adjusted OR, 0.32; 95% CI, 0.12 – 0.87) independently of maternal filarial infection which tended to reduce the child’s risk for being SPT positive (adjusted OR, 0.35; 95% CI, 0.07 – 1.70).

Conclusions

In areas endemic for helminths, potent TH₂ responses were seen early in life, but did not translate into a higher SPT reactivity to allergens. Therefore, in many parts of the world TH₂ responses in general and IgE in particular cannot be used for diagnosis of allergic diseases.

【 授权许可】

   
2013 Djuardi et al.; licensee BioMed Central Ltd.

【 图 表 】

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