Aberrant amygdala functional connectivity at rest in pediatric anxiety disorders

Biology of Mood & Anxiety Disorders

Lisa L Hamm²  Rachel H Jacobs²  Meghan W Johnson²  Daniel A Fitzgerald²  Kate D Fitzgerald¹  Scott A Langenecker²  Christopher S Monk⁴  K Luan Phan³ 

[1] Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA

[2] Department of Psychiatry, University of Illinois at Chicago, 1747 W. Roosevelt Road, IJR/WROB Rm. 244, Chicago 60608, IL, USA

[3] Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois, USA

[4] Department of Psychology, University of Michigan, Ann Arbor, Michigan, USA

关键词: fMRI;    Resting state;    Connectivity;    Amygdala;    Anxiety;    Adolescent;    Children;   

Others  :  1084029
DOI  :  10.1186/s13587-014-0015-4

 received in 2014-08-29, accepted in 2014-11-28,  发布年份 2014

【 摘 要 】

Background

Childhood onset of anxiety disorders is associated with greater functional impairment and burden across the lifespan. Recent work suggests that generalized anxiety disorder (GAD) is characterized by dysfunctional connectivity in amygdala-based circuits at rest in adolescents, consistent with adults. However, neural mechanisms underlying a broad spectrum of often-comorbid anxiety disorders in children remains unclear and understudied. The current study examines amygdala functional connectivity at rest in children and adolescents across comorbid anxiety disorders (ADs) including youth with primary diagnoses of GAD and social phobia (SP).

Results

Compared with healthy controls (HCs), AD youth exhibited hyperconnectivity between the right amygdala and the insula and hypoconnectivity between the left amygdala and the ventromedial prefrontal cortex (vmPFC) and posterior cingulate cortex (PCC). Within the AD group, connectivity was not correlated with anxiety severity and only the amygdala-PCC connectivity was positively correlated with age.

Conclusions

Our findings indicate that youth with comorbid ADs demonstrate aberrant connectivity in the anterior limbic network (ALN) as well as the PCC at rest. This extends upon previous work suggesting alterations in amygdala circuits underlying fear learning, emotion regulation, and the processing of interoceptive states. Presence of these findings within this young, comorbid sample points to underlying common mechanisms across ADs and illuminates future targets for prevention and intervention in childhood.

【 授权许可】

   
2014 Hamm et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

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