Why the Central Dogma: on the nature of the great biological exclusion principle

Biology Direct

Eugene V. Koonin¹ 

[1] National Center for Biotechnology Information, National Library of Medicine, National Instittues of Health, Bethesda 20894, MD, USA

关键词: Aminoacyl-tRNA synthetases;    Translation;    Analogous information;    Digital information;    Central Dogma;   

Others  :  1230704
DOI  :  10.1186/s13062-015-0084-3

 received in 2015-07-08, accepted in 2015-09-14,  发布年份 2015

【 摘 要 】

The Central Dogma of molecular biology posits that transfer of information from proteins back to nucleic acids does not occur in biological systems. I argue that the impossibility of reverse translation is indeed a major, physical exclusion principle that emerges due to the transition from the digital information carriers, nucleic acids, to analog information carriers, proteins, which involves irreversible suppression of the digital information.

【 授权许可】

   
2015 Koonin.

【 图 表 】

Fig. 1.

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