Amoxicillin rash in patients with infectious mononucleosis: evidence of true drug sensitization

Allergy, Asthma & Clinical Immunology

Katinka Ónodi-Nagy²  Ágnes Kinyó²  Angéla Meszes²  Edina Garaczi²  Lajos Kemény¹  Zsuzsanna Bata-Csörgő¹ 

[1] Dermatological Research Group of the Hungarian Academy of Sciences, University of Szeged, Szeged, Hungary

[2] Department of Dermatology and Allergology, University of Szeged, Albert Szent-Györgyi Medical Center, Korányi fasor 6, Szeged 6720, Hungary

关键词: Drug tests;    Infectious mononucleosis;    Sensitization to antibiotics;    Amoxicillin;   

Others  :  1089004
DOI  :  10.1186/1710-1492-11-1

 received in 2014-04-01, accepted in 2014-10-08,  发布年份 2015

【 摘 要 】

Background

It hasn’t been clearly understood yet whether sensitization to antibiotics, the virus itself or transient loss of drug tolerance due to the virus, is responsible for the development of maculopapular exanthems following amoxicillin intake in patients with infectious mononucleosis. We aimed to examine whether sensitization to penicillin developed among patients with skin rash following amoxicillin treatment within infectious mononucleosis.

Methods

Ten patients were investigated for drug sensitization by lymphocyte transformation test and six patients were further tested by prick-, intradermal and patch tests employing the penicillin’s main antigens.

Results

Lymphocyte transformation test showed negative results with amoxicillin, while one patient had positive reaction to cefixime. Six patients with suspected sensitization to amoxicillin were then investigated by in vivo tests. Prick tests were negative in all six patients, but the intradermal tests showed positive reactions in four patients.

Conclusions

Our data demonstrate that in vitro testing is not sensitive enough in determining drug sensitization to penicillin. In vivo tests should be performed to detect sensitization and indeed with skin tests our results confirmed that sensitization to aminopenicillin may develop within infectious mononucleosis.

【 授权许可】

   
2015 Ónodi-Nagy et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

Figure 2.

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