A common haplotype of KIAA0319 contributes to the phonological awareness skill in Chinese children

Behavioral and Brain Functions

Cadmon King-Poo Lim¹  Amabel May-Bo Wong¹  Connie Suk-Han Ho²  Mary Mui-Yee Waye¹ 

[1] Croucher Laboratory for Human Genomics, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong

[2] Department of Psychology, The University of Hong Kong, Pokfulam, Hong Kong

关键词: Phonological awareness;    Chinese population;    Dyslexia;    KIAA0319;   

Others  :  1084021
DOI  :  10.1186/1744-9081-10-23

 received in 2014-01-18, accepted in 2014-06-27,  发布年份 2014

【 摘 要 】

Background

Previous studies have shown that KIAA0319 is a candidate gene for dyslexia in western populations. In view of the different languages used in Caucasian and Chinese populations, the aim of the present study was to investigate whether there is also an association of KIAA0319 in Chinese children with dyslexia and/or to the language-related cognitive skills.

Method and results

A total of twenty six single nucleotide polymorphisms (SNPs) were genotyped from three hundred and ninety three individuals from 131 Chinese families. Four of the SNPs have been reported in the literature and twenty two being tag SNPs at KIAA0319. Analysis for allelic and haplotypic associations was performed with the UNPHASED program and multiple testing was corrected using permutation. Results indicate that KIAA0319 is not associated with Chinese children with dyslexia but a haplotype consisting of rs2760157 and rs807507 SNPs were significantly associated with an onset detection test, a measure of phonological awareness (p_nominal = 6.85 10^-5 and p_corrected = 0.0029).

Conclusion

In conclusion, our findings suggest that KIAA0319 is associated with a reading-related cognitive skill.

【 授权许可】

   
2014 Lim et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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