A rare case of endometrioma in a bitch

Acta Veterinaria Scandinavica

Bruno H. A. Paiva²  Juneo F. Silva²  Natália M. Ocarino²  Cleida A. Oliveira¹  Wiviane A. Assis¹  Rogéria Serakides² 

[1] Laboratório de Biologia da Reprodução do Departamento de Morfologia, Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627, CEP: 30.161-970, Belo Horizonte, Minas Gerais, Brazil

[2] Laboratório de Patologia do Departamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária da Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627, CEP: 30.161-970, Belo Horizonte, Minas Gerais, Brazil

关键词: Bitch;    Coelomic metaplasia;    Endometrioma;    Endometriosis;   

Others  :  1218465
DOI  :  10.1186/s13028-015-0123-1

 received in 2014-11-10, accepted in 2015-06-16,  发布年份 2015

【 摘 要 】

Background

Endometriosis is ectopic development of endometrial glands and stroma in extra-uterine sites and if the lesions occur as a well-defined mass is referred to as endometrioma. In the literature, endometrioma has been reported in only women and there are no reports of endometrioma in animals, including non-human primates.

Case presentation

A rare case of endometrioma is reported in an 11-year-old female German Shepherd with clinical signs of dehydration, anemia and prostration. Necropsy revealed ascites, generalized pallor, and a well-demarcated reddish mass adjacent to the left ovary and uterus and adherent to the retroperitoneum. The mass measured 25.0 × 20.0 cm with intermingled soft and firm areas. Upon incision, the mass was found to be solid with variable sized cystic cavities filled with coagulated blood. Microscopically, the mass was composed of cuboidal or prismatic epithelial cells arranged in tubules or acini. The epithelium of the mass had similar characteristics to the normal endometrium with PAS-positive secretions. The stroma was prominent and formed by loose connective tissue and smooth muscle fibers as confirmed by Masson trichrome. Extensive multifocal areas of hemorrhage were also observed in the stroma of the mass and in the interior of some epithelium-lined, cystic structures. Most of the epithelial cells had strong and diffuse cytokeratin expression, and some had vimentin expression. Epithelial and stromal cells also showed ERβ, AR, VEGF and COX2 expression. The stroma showed areas with strong and diffuse vimentin expression. Factor VIII expression was observed only in the endothelium of blood vessels in the stroma.

Conclusions

The macroscopic, microscopic and immunohistochemical findings are consistent with an endometrioma.

【 授权许可】

   
2015 Paiva et al.

【 图 表 】

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