Cardiac arrhythmias and electrolyte disturbances in colic horses

Acta Veterinaria Scandinavica

Eva Z Hesselkilde¹  Mette E Almind¹  Jesper Petersen¹  Mette Flethøj¹  Kirstine F Præstegaard¹  Rikke Buhl¹ 

[1] Department of Large Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Højbakkegård Allé 5, Taastrup, DK-2630, Denmark

关键词: Electrolytes;    Heart rate;    Arrhythmias;    ECG;    Colic;    Equine;   

Others  :  1082549
DOI  :  10.1186/s13028-014-0058-y

 received in 2014-04-25, accepted in 2014-08-29,  发布年份 2014

【 摘 要 】

Background

Despite increased focus on cardiac arrhythmias in horses, the nature and prevalence is still poorly described. Case reports suggest that arrhythmias occurring secondary to systemic disease are seen more commonly in the clinic than arrhythmias caused by cardiac disease. The aim of this study was to investigate the prevalence of arrhythmias in colic horses referred for hospital treatment. Associations between electrolyte disturbances and arrhythmias were also investigated.

The study population consisted of eight control horses and 22 referred colic horses. A Holter electrocardiography (ECG) was recorded during the first 24 hours of admission. The ECG’s were analysed by a software program followed by manual visual inspection. Arrhythmias registered included second degree atrioventricular (AV) blocks, supraventricular premature complexes (SVPCs), and ventricular premature complexes (VPCs). Blood was collected at admission and again between 12 and 24 hours after ECG was applied, and analysed for concentrations of potassium, sodium, ionised calcium, chloride, glucose, and L-lactate.

Results

Heart rate was 37.4 ± 3.7 bpm in the control group, and 51.6 ± 11.8 bpm, in the colic group, which was significantly different (P < 0.0001). AV blocks and SVPCs were found in both groups, however only colic horses showed VPCs. No significant difference between the two groups was found for AV blocks, SVPCs, and VPCs (P = 0.08 - 0.76). The mean levels of potassium, sodium, ionized calcium, and chloride were significantly lower in the colic group compared to the control group at admission. Mean levels of glucose and L-lactate were significantly elevated in the colic group (P < 0.05).

Conclusions

This study describes prevalence of cardiac arrhythmias and electrolytes concentrations in colic horses compared to healthy controls. Although we only observed VPCs in the colic horses, no significant differences between colic horses and controls were found. Despite the colic horses having electrolyte changes at admission no correlation was found between the electrolyte disturbances and cardiac arrhythmias. Although no clear conclusions can be drawn from the present study, the results indicate that relatively mild colic per se is not pro-arrhythmogenic, whereas severe colic probably are more likely to result in ventricular arrhythmia.

【 授权许可】

   
2014 Hesselkilde et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

【 参考文献 】

• [1]Barbesgaard L, Buhl R, Meldgaard C: Prevalence of exercise-associated arrhythmias in normal performing dressage horses. Equine Vet J 2010, 42(Suppl 38):202-207.
• [2]Buhl R, Meldgaard C, Barbesgaard L: Cardiac arrhythmias in clinically healthy showjumping horses. Equine Vet J 2010, 42(Suppl 38):196-201.
• [3]Buhl R, Petersen EE, Lindholm M, Bak L, Nostell K: Cardiac arrhythmias in Standardbreds during and after racing – possible association between heart size, valvular regurgitations and arrhythmias. J Equine Vet Sci 2013, 33:590-596.
• [4]Cornick JL, Seahorn TL: Cardiac arrhythmias identified in horses with duodenitis/proximal jejunitis. Six cases (1985-1988). J Am Vet Med Assoc 1990, 197:1054-1059.
• [5]Leroux AA, Detilleux J, Sandersen CF, Borde L, Houben RM, Al Haidar A, Art T, Amory H: Prevalence and risk factors for cardiac diseases in a hospital-based population of 3,434 horses (1994-2011). J Vet Intern Med 2013, 27:1563-1570.
• [6]Morgan RA, Raftery AG, Cripps P, Senior JM, McGowan CM: The prevalence and nature of cardiac arrhythmias in horses following general anaesthesia and surgery. Acta Vet Scand 2011, 53:3-8. BioMed Central Full Text
• [7]Matthews NS, Hartsfield SM: Arrhythmogenic dose of epinephrine in isoflurane or sevoflurane anaesthetized horses. J Equine Vet Sci 2004, 24:110-114.
• [8]Reimer JM, Reef VB, Sweeney RW: Ventricular arrhythmias in horses: 21 cases (1984-1989). J Am Vet Med Assoc 1992, 201:1237-1243.
• [9]Feldman EC, Ettinger SJ: Electrocardiographic changes associated with electrolyte disturbances. Vet Clin North America 1977, 7:487-496.
• [10]Schaer M: Disorders of serum potassium, sodium, magnesium and chloride. J Vet Emerg Crit Care 1999, 9:209-217.
• [11]Corley KTT, Marr CM: Cardiac monitoring in the ICU patient. Clin Tech Equine Prac 2003, 2:145-155.
• [12]Bonagura JD, Miller MS: Common conduction disturbances. J Equine Vet Sci 1986, 6:23-25.
• [13]Raekallio M: Long-term ECG recording with Holter monitoring in clinically healthy horses. Acta Vet Scand 1992, 33:71-75.
• [14]Scheffer CWJ, Robben JH, Sloet van Oldruitenborgh-Oosterbaan MM: Continuous monitoring of ECG in horses at rest and during exercise. Vet Rec 1995, 137:371-374.
• [15]Ohmura H, Hiraga A, Aida H, Kuwahara M, Tsubone H, Jones JH: Effects of repeated atropine injection on heart rate variability in Thoroughbred horses. J Vet Med Sci 2001, 63:1359-1360.
• [16]Kuwahara M, Hashimoto S, Ishii K, Yagi Y, Hada T, Hiraga A, Kai M, Kubo K, Oki H, Tsubone H, Sugano S: Assessment of autonomic nervous function by power spectral analysis of heart rate variability in the horse. J Auton Nerv Syst 1996, 60:43-48.
• [17]Hamlin RL, Klepinger WL, Gilpin KW, Smith CR: Autonomic control of heart rate in the horse. Am J Physiol 1972, 222:976-978.
• [18]Raekallio M, Vainio O, Karjalainen J: The influence of detomidine and epinephrine on heart rate, arterial blood pressure, and cardiac arrhythmia in horses. Vet Surgery 1991, 20:468-473.
• [19]Physick-Sheard PW, McGurrin MKJ: Ventricular arrhythmias during race recovery in Standardbred racehorses and associations with autonomic activity. J Vet Intern Med 2010, 24:1158-1166.
• [20]Nostell K, Bröjera J, Höglund K, Ednera A, Häggström J: Cardiac troponin I and the occurrence of cardiac arrhythmias in horses with experimentally induced endotoxaemia. Vet J 2012, 192:171-175.
• [21]Dart AJ, Snyder JR, Spier SJ, Sullivan KE: Ionized calcium concentration in horses with surgically managed gastrointestinal disease: 147 cases (1988-1990). J Am Vet Med Assoc 1992, 201:1244-1248.
• [22]Larsen J: Acid-base and Electrolyte Balance in Horses with Various Gastrointestinal Disorders. In Proceedings of the fifth Equine Colic Research Symposium: September 25-28 1994. Edited by Barton MH, Moore JN, White NA. Center for Continuing Education, University of Georgia, 1994, Athens; 1994:9.
• [23]Garcia-Lopez JM, Provost PJ, Rush JE, Zicker SC, Burmaster H, Freeman LM: Prevalence and prognostic importance of hypomagnesemia and hypocalcemia in horses that have colic surgery. Am J Vet Res 2001, 62:7-11.
• [24]Johansson AM, Gardner SY, Jones SL, Fuquay LR, Reagan VH, Levine JF: Hypomagnesaemia in hospitalized horses. J Vet Intern Med 2003, 17:860-867.
• [25]Nappert G, Johnson PJ: Determination of the acid-base status in 50 horses admitted with colic between December 1998 and May 1999. Can Vet J 2001, 42:703-707.
• [26]Navarro M, Monreal L, Segura D, Armengou L, Añor S: A comparison of traditional and quantitative analysis of acid-base and electrolyte imbalances in horses with gastrointestinal disorders. J Vet Intern Med 2005, 19:871-877.
• [27]Johnson PJ: Electrolyte and acid-base disturbances in the horse. Vet Clin North Am Equine Pract 1995, 11:491-514.
• [28]Borer KE, Corley KTT: Electrolyte disorders in horses with colic. Part 2: Calcium, sodium, chloride and phosphate. Equine Vet Educ 2006, 18:320-325.
• [29]Gennari FJ: Hypokalemia. N Engl J Med 1998, 339:451-458.
• [30]Langouche L, Van den Berghe G: Glucose metabolism and insulin therapy. Crit Care Clin 2006, 22:119-129.
• [31]Hollis AR, Boston RC, Corley KTT: Blood glucose in horses with acute abdominal disease. J Vet Intern Med 2007, 21:1099-1103.