Neurocognitive therapeutics: from concept to application in the treatment of negative attention bias

Biology of Mood & Anxiety Disorders

David M Schnyer⁴  Christopher G Beevers⁴  Megan T deBettencourt²  Stephanie M Sherman³  Jonathan D Cohen¹  Kenneth A Norman¹  Nicholas B Turk-Browne¹ 

[1] Department of Psychology and Princeton Neuroscience Institute, Princeton University, Princeton 08540-1010, NJ, USA

[2] Princeton Neuroscience Institute, Princeton University, Princeton 08540-1010, NJ, USA

[3] Department of Psychology, University of Texas at Austin, Austin 78712, TX, USA

[4] Department of Psychology & Institute for Mental Health Research, University of Texas at Austin, Austin 78712, TX, USA

关键词: fMRI;    Mood disorders;    Multivoxel pattern analysis (MVPA);    Real-time neurofeedback;    Attention bias;   

Others  :  1207573
DOI  :  10.1186/s13587-015-0016-y

 received in 2015-02-17, accepted in 2015-04-07,  发布年份 2015

【 摘 要 】

There is growing interest in the use of neuroimaging for the direct treatment of mental illness. Here, we present a new framework for such treatment, neurocognitive therapeutics. What distinguishes neurocognitive therapeutics from prior approaches is the use of precise brain-decoding techniques within a real-time feedback system, in order to adapt treatment online and tailor feedback to individuals’ needs. We report an initial feasibility study that uses this framework to alter negative attention bias in a small number of patients experiencing significant mood symptoms. The results are consistent with the promise of neurocognitive therapeutics to improve mood symptoms and alter brain networks mediating attentional control. Future work should focus on optimizing the approach, validating its effectiveness, and expanding the scope of targeted disorders.

【 授权许可】

   
2015 Schnyer et al.; licensee Biomed Central.

【 图 表 】

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