Neuroimaging studies of pediatric social anxiety: paradigms, pitfalls and a new direction for investigating the neural mechanisms

Biology of Mood & Anxiety Disorders

Eric E Nelson³  Daniel S Pine³  Nathan A Fox¹  Olga Lydia Walker⁴  Ellen Leibenluft²  Johanna M Jarcho³ 

[1]Department of Quantitative Methodology, University of Maryland, College Park, MD 20742, USA

[2]Section on Bipolar Spectrum Disorders, National Institute of Mental Health, Bethesda, MD 20892, USA

[3]Section on Developmental and Affective Neuroscience, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Building 15 K, Bethesda, MD 20892, USA

[4]Department of Human Development, University of Maryland, College Park, MD 20742, USA

关键词: Bullying;    Peer victimization;    Response flexibility;    Behavioral inhibition;    Affect;    Social cognition;    Uncertainty;    Peers;    Development;    fMRI;   

Others  :  791906
DOI  :  10.1186/2045-5380-3-14

 received in 2013-02-20, accepted in 2013-05-24,  发布年份 2013

【 摘 要 】

Social Anxiety Disorder (SAD) is a common and debilitating condition that typically manifests in adolescence. Here we describe cognitive factors engaged by brain-imaging tasks, which model the peer-based social interactions that evoke symptoms of SAD. We then present preliminary results from the Virtual School paradigm, a novel peer-based social interaction task. This paradigm is designed to investigate the neural mechanisms mediating individual differences in social response flexibility and in participants’ responses to uncertainty in social contexts. We discuss the utility of this new paradigm for research on brain function and developmental psychopathology.

【 授权许可】

   
2013 Jarcho et al.; licensee BioMed Central Ltd.

【 图 表 】

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