Steroid concentrations in antepartum and postpartum saliva: normative values in women and correlations with serum

Biology of Sex Differences

Elizabeth Hampson¹  Shauna-Dae Phillips²  Claudio N Soares²  Meir Steiner² 

[1] Department of Psychology and Graduate Program in Neuroscience, University of Western Ontario, London, ON, Canada

[2] Women’s Health Concerns Clinic, St. Joseph’s Healthcare; Department of Psychiatry and Behavioural Neurosciences and Obstetrics & Gynecology, McMaster University, Hamilton, ON, Canada

关键词: Hormone;    Gestation;    Postpartum;    Pregnancy;    Radioimmunoassay;    Enzyme immunoassay;    Steroid;    Saliva;   

Others  :  793262
DOI  :  10.1186/2042-6410-4-7

 received in 2013-01-02, accepted in 2013-03-22,  发布年份 2013

【 摘 要 】

Background

Saliva has been advocated as an alternative to serum or plasma for steroid monitoring. Little normative information is available concerning expected concentrations of the major reproductive steroids in saliva during pregnancy and the extended postpartum.

Methods

Matched serum and saliva specimens controlled for time of day and collected less than 30 minutes apart were obtained in 28 women with normal singleton pregnancies between 32 and 38 weeks of gestation and in 43 women during the first six months postpartum. Concentrations of six steroids (estriol, estradiol, progesterone, testosterone, cortisol, dehydroepiandrosterone) were quantified in saliva by enzyme immunoassay.

Results

For most of the steroids examined, concentrations in antepartum saliva showed linear increases near end of gestation, suggesting an increase in the bioavailable hormone component. Observed concentrations were in agreement with the limited data available from previous reports. Modal concentrations of the ovarian steroids were undetectable in postpartum saliva and, when detectable in individual women, approximated early follicular phase values. Only low to moderate correlations between the serum and salivary concentrations were found, suggesting that during the peripartum period saliva provides information that is not redundant to serum.

Conclusions

Low correlations in the late antepartum may be due to differential rates of change in the total and bioavailable fractions of the circulating steroid in the final weeks of the third trimester as a consequence of dynamic changes in carrier proteins such as corticosteroid binding globulin.

【 授权许可】

   
2013 Hampson et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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