Effects of acute hypoxia on heart rate variability, sample entropy and cardiorespiratory phase synchronization

BioMedical Engineering OnLine

Da Zhang³  Jin She³  Zhengbo Zhang²  Mengsun Yu¹ 

[1] Research Center of Aviation Medicine Engineering, Institute of Aviation Medicine, Beijing, China

[2] Department of Biomedical Engineering, Chinese PLA (People’s Liberation Army) General Hospital, Beijing, China

[3] School of Biological Science and Medical Engineering, Beihang University, Beijing, China

关键词: Cardiorespiratory phase synchronization;    Sample entropy;    Heart rate variability;    Autonomic nervous system;    Hypoxia;   

Others  :  793144
DOI  :  10.1186/1475-925X-13-73

 received in 2014-02-04, accepted in 2014-06-06,  发布年份 2014

【 摘 要 】

Background

Investigating the responses of autonomic nervous system (ANS) in hypoxia may provide some knowledge about the mechanism of neural control and rhythmic adjustment. The integrated cardiac and respiratory system display complicated dynamics that are affected by intrinsic feedback mechanisms controlling their interaction. To probe how the cardiac and respiratory system adjust their rhythms in different simulated altitudes, we studied heart rate variability (HRV) in frequency domain, the complexity of heartbeat series and cardiorespiratory phase synchronization (CRPS) between heartbeat intervals and respiratory cycles.

Methods

In this study, twelve male subjects were exposed to simulated altitude of sea level, 3000 m and 4000 m in a hypobaric chamber. HRV was assessed by power spectral analysis. The complexity of heartbeat series was quantified by sample entropy (SampEn). CRPS was determined by cardiorespiratory synchrogram.

Results

The power spectral HRV indices at all frequency bands depressed according to the increase of altitude. The SampEn of heartbeat series increased significantly with the altitude (P < 0.01). The duration of CRPS epochs at 3000 m was not significantly different from that at sea level. However, it was significantly longer at 4000 m (P < 0.01).

Conclusions

Our results suggest the phenomenon of CRPS exists in normal subjects when they expose to acute hypoxia. Further, the autonomic regulation has a significantly stronger influence on CRPS in acute hypoxia. The changes of CRPS and HRV parameters revealed the different regulatory mechanisms of the cardiac and respiratory system at high altitude.

【 授权许可】

   
2014 Zhang et al.; licensee BioMed Central Ltd.

【 图 表 】

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