Sex and gonadal hormones in mouse models of Alzheimer’s disease: what is relevant to the human condition?

Biology of Sex Differences

Dena B Dubal¹  Lauren Broestl¹  Kurtresha Worden¹ 

[1] Laboratory of Neuroscience and Aging Research, Department of Neurology, Sandler Neurosciences Center, Room 212B, University of California, San Francisco, San Francisco, CA 94158, USA

关键词: Andropause;    Menopause;    Reproductive aging;    Aging;    Human;    Mouse;    Transgenic;    Pathology;    Behavior;    Cognition;    Androgens;    Testosterone;    Progesterone;    Estrogen;    Hormones;    Sex chromosomes;    Neurodegeneration;    Tau;    Aβ;    Alzheimer’s disease;    Brain;    Gender;    Sex;   

Others  :  793407
DOI  :  10.1186/2042-6410-3-24

 received in 2012-08-09, accepted in 2012-09-27,  发布年份 2012

【 摘 要 】

Biologic sex and gonadal hormones matter in human aging and diseases of aging such as Alzheimer’s – and the importance of studying their influences relates directly to human health. The goal of this article is to review the literature to date on sex and hormones in mouse models of Alzheimer’s disease (AD) with an exclusive focus on interpreting the relevance of findings to the human condition. To this end, we highlight advances in AD and in sex and hormone biology, discuss what these advances mean for merging the two fields, review the current mouse model literature, raise major unresolved questions, and offer a research framework that incorporates human reproductive aging for future studies aimed at translational discoveries in this important area. Unraveling human relevant pathways in sex and hormone-based biology may ultimately pave the way to novel and urgently needed treatments for AD and other neurodegenerative diseases.

【 授权许可】

   
2012 Dubal et al.; licensee BioMed Central Ltd.

【 图 表 】

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