Dexmedetomidine decreases the emergence agitation in infant patients undergoing cleft palate repair surgery after general anesthesia

BMC Anesthesiology

TieJun Zhang¹  Wei Peng¹ 

[1]Department of Anesthesiology, School and Hospital of Stomatology, Wuhan University, No. 237 Luoyu Street, Wuhan 430079, Hubei, China

关键词: General anesthesia;    Sevoflurane;    Cleft palate repair surgery;    Emergence agitation;    Dexmedetomidine;   

Others  :  1228350
DOI  :  10.1186/s12871-015-0124-7

 received in 2015-04-22, accepted in 2015-10-03,  发布年份 2015

【 摘 要 】

Background

To determine whether continuous intravenous infusion of dexmedetomidine (DEX) can affect the incidence of Emergence Agitation (EA) after general anesthesia in infant undergoing cleft palate repair surgery.

Methods

Forty infants underwent cleft palate repair surgery under general anesthesia were randomly divided into the DEX (D) group and Placebo (P) groups. Patients in group D received continuous intravenous infusion of DEX 0.8 μg · kg-1 · min-1 after the induction. Patients in group P were administered with continuous intravenous infusion of the equivalent volume of normal saline. Both groups were induced with fentanyl 0.005 mg/Kg, propofol 2 mg/Kg and cisatracurium 0.2 mg/Kg. Anaesthesia was maintained with continuous intravenous infusion of propofol (2 mg/Kg · h), remifentanil (0.1 μg/Kg · h), and inhalation of 1 to 3 % sevoflurane.

Result

The heart rate (HR) in group P was significant higher than that in group D at the time of operation (P < 0.05), postoperative 15 min, 30 min and the time of extubation (P < 0.01). The mean arterial pressure (MAP) in group P was higher comparing with MAP in group D at the time of extubation (P < 0.05). The spontaneous eye opening times and spontaneous arm or leg motion times were longer in group D (P < 0.05). The mean agitation scores of patients in group D were significantly lower than that in group P (P < 0.01). However, the incidence of EA in group P and group D was 90 % and 15 % (P <0.05).

Conclusion

The continuous intravenous infusion of DEX after induction could significantly reduce the occurrence of EA.

Trial registration

The Chinese Clinical Trial Register ChiCTR-TRC-13003865

【 授权许可】

   
2015 Peng and Zhang.

【 图 表 】

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