Association of cadmium with diabetes in middle-aged residents of abandoned metal mines: the first health effect surveillance for residents in abandoned metal mines

Annals of Occupational and Environmental Medicine

Joon Sakong³  Jai-dong Moon⁷  Byung-kook Lee²  Jung-duck Park⁴  Yeong-seoub Hong¹  Seung-do Yu⁸  Dae-seon Kim⁸  Dong-uk Park⁵  Byung-seong Suh⁶  Soo-geun Kim⁶  Hee-seung Son⁶ 

[1]Department of Preventive Medicine, School of Medicine, Dong-A University, Busan, Republic of Korea

[2]Korean Industrial Health Association, Hyesan Bldg., Seoul, Republic of Korea

[3]Department of Preventive Medicine and Public Health, College of Medicine, Yeungnam University, Daegu, Republic of Korea

[4]Department of Preventive Medicine, College of Medicine, Chung-Ang University, Seoul, Republic of Korea

[5]Department of Environmental Health, Korea National Open University, Seoul, Republic of Korea

[6]Department of 1Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Medical Center of Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

[7]Department of Preventive Medicine and Public Health, College of Medicine, Chonnam National University Hwasun Hospital, Hwasun, Republic of Korea

[8]Environmental Health Research Department, Environmental Health Research Division, Incheon, Republic of Korea

关键词: Environmental disorder;    Glucose;    Abandoned mine;    Diabetes;    Urine cadmium;   

Others  :  1223784
DOI  :  10.1186/s40557-015-0071-2

 received in 2015-01-14, accepted in 2015-07-29,  发布年份 2015

【 摘 要 】

Objective

The aim of this study was to determine the association between urinary cadmium (U-cd) concentration and diabetes in middle-aged Korean residents of abandoned mines using the first Health Effect Surveillance for Residents in Abandoned Metal mines (HESRAM).

Methods

This study was cross-sectional study conducted on 719 residents between 40–70 years in 38 abandoned metal mines in Korea. Data was collected by HESRAM from 2008 to 2011. The correlation coefficient of U-cd and fasting blood glucose, odds ratio in urinary cadmium tertiles and diabetes prevalence was analyzed according to the sex category.

Results

The correlation coefficient U-cd concentration and fasting blood glucose was 0.182 in male. Logistic regression analysis in male revealed a third tertile odds ratio of U-cd (2 μg/g creatinine < U-cd) while diabetes prevalence was 1.81 (95 % CI 1.05-3.12) with adjusted age, BMI, smoking and alcohol consumption, region, family income. On the other hand, the odds ratio for third tertile of U-cd (3 μg/g creatinine < U-cd) between diabetes prevalence in female was 1.39 (95 % CI 0.52-3.72) in addition to adjusted menopausal status.

Conclusions

Environmental exposure to cadmium in abandoned mine residents was associated with diabetes in male. Closed monitoring and periodic evaluation of the health effects of chronic environmental exposure on abandoned mines residents will be needed.

【 授权许可】

   
2015 Son et al.

【 图 表 】

Fig. 1.

【 参考文献 】

• [1]Coelho P, Silva S, Roma-Torres J, Costa C, Henriques A, Teixeira J et al.. Health impact of living near an abandoned mine--case study: Jales mines. Int J Hyg Environ Health. 2007; 210(3–4):399-402.
• [2]Henson MC, Chedrese PJ. Endocrine disruption by cadmium, a common environmental toxicant with paradoxical effects on reproduction. Exp Biol Med. 2004; 229(5):383-92.
• [3]Hwangbo Y, Weaver VM, Tellez-Plaza M, Guallar E, Lee BK, Navas-Acien A. Blood cadmium and estimated glomerular filtration rate in Korean adults. Environ Health Perspect. 2011; 119(12):1800-5.
• [4]Liu J, Qu W, Kadiiska MB. Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicol Appl Pharmacol. 2009; 238(3):209-14.
• [5]Rathmann W, Giani G. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004; 27(10):2568-9.
• [6]Cho NH. The epidemiology of diabetes in Korea: from the economics to genetics. Korean Diabetes J. 2010; 34(1):10-5.
• [7]Standards of medical care in diabetes--2010. Diabetes Care. 2010; 33 Suppl 1:S11-61.
• [8]El Muayed M, Raja MR, Zhang X, MacRenaris KW, Bhatt S, Chen X et al.. Accumulation of cadmium in insulin-producing beta cells. Islets. 2012; 4(6):405-16.
• [9]Gerson RJ, Shaikh ZA. Uptake and binding of cadmium and mercury to metallothionein in rat hepatocyte primary cultures. Biochem. J. 1982; 208(2):465-72.
• [10]Liuzzi JP, Bobo JA, Lichten LA, Samuelson DA, Cousins RJ. Responsive transporter genes within the murine intestinal-pancreatic axis form a basis of zinc homeostasis. Proc Natl Acad Sci U S A. 2004; 101(40):14355-60.
• [11]Serdar MA, Bakir F, Hasimi A, Celik T, Akin O, Kenar L et al.. Trace and toxic element patterns in nonsmoker patients with noninsulin-dependent diabetes mellitus, impaired glucose tolerance, and fasting glucose. Int J Diabetes Dev Ctries. 2009; 29(1):35-40.
• [12]Schwartz GG, Il’yasova D, Ivanova A. Urinary cadmium, impaired fasting glucose, and diabetes in the NHANES III. Diabetes Care. 2003; 26(2):468-70.
• [13]Moon SS. Association of lead, mercury and cadmium with diabetes in the Korean population: the Korea National Health and Nutrition Examination Survey (KNHANES) 2009–2010. Diabetic Med. 2013; 30(4):e143-8.
• [14]Elinder CG, Lind B, Kjellstrom T, Linnman L, Friberg L. Cadmium in kidney cortex, liver, and pancreas from Swedish autopsies. Estimation of biological half time in kidney cortex, considering calorie intake and smoking habits. Arch Environ Health. 1976; 31(6):292-302.
• [15]Park DU, Kim DS, Yu SD, Lee KM, Ryu SH, Kim SG et al.. Blood levels of cadmium and lead in residents near abandoned metal mine areas in Korea. Environ Monit Assess. 2014; 186(8):5209-20.
• [16]Godt J, Scheidig F, Grosse-Siestrup C, Esche V, Brandenburg P, Reich A et al.. The toxicity of cadmium and resulting hazards for human health. J Occup Med Toxicol. 2006; 1:22. BioMed Central Full Text
• [17]Weaver VM, Kim NS, Jaar BG, Schwartz BS, Parsons PJ, Steuerwald AJ et al.. Associations of low-level urine cadmium with kidney function in lead workers. Occup Environ Med. 2011; 68(4):250-6.
• [18]Osada M, Izuno T, Kobayashi M, Sugita M. Relationship between environmental exposure to cadmium and bone metabolism in a non-polluted area of Japan. Environ Health Prev Med. 2011; 16(6):341-9.
• [19]Chaumont A, Voisin C, Deumer G, Haufroid V, Annesi-Maesano I, Roels H et al.. Associations of urinary cadmium with age and urinary proteins: further evidence of physiological variations unrelated to metal accumulation and toxicity. Environ Health Perspect. 2013; 121(9):1047-53.
• [20]Olsson IM, Bensryd I, Lundh T, Ottosson H, Skerfving S, Oskarsson A. Cadmium in blood and urine--impact of sex, age, dietary intake, iron status, and former smoking--association of renal effects. Environ Health Perspect. 2002; 110(12):1185-90.
• [21]Lee HY, Won JC, Kang YJ, Yoon SH, Choi EO, Bae JY et al.. Type 2 diabetes in urban and rural districts in Korea: factors associated with prevalence difference. J Korean Med Sci. 2010; 25(12):1777-83.
• [22]Dunstan DW, Zimmet PZ, Welborn TA, De Courten MP, Cameron AJ, Sicree RA et al.. The rising prevalence of diabetes and impaired glucose tolerance: the Australian Diabetes Obesity and Lifestyle Study. Diabetes Care. 2002; 25(5):829-34.
• [23]McDermott R, Rowley KG, Lee AJ, Knight S, O’Dea K. Increase in prevalence of obesity and diabetes and decrease in plasma cholesterol in a central Australian aboriginal community. Med J Aust. 2000; 172(10):480-4.
• [24]Afridi HI, Kazi TG, Kazi N, Jamali MK, Arain MB, Jalbani N et al.. Evaluation of status of toxic metals in biological samples of diabetes mellitus patients. Diabetes Res Clin Pract. 2008; 80(2):280-8.
• [25]Barregard L, Bergstrom G, Fagerberg B. Cadmium exposure in relation to insulin production, insulin sensitivity and type 2 diabetes: a cross-sectional and prospective study in women. Environ Res. 2013; 121:104-9.
• [26]Swaddiwudhipong W, Mahasakpan P, Limpatanachote P, Krintratun S. Correlations of urinary cadmium with hypertension and diabetes in persons living in cadmium-contaminated villages in northwestern Thailand: A population study. Environ Res. 2010; 110(6):612-6.
• [27]Nilsson T, Rorsman F, Berggren PO, Hellman B. Accumulation of cadmium in pancreatic beta cells is similar to that of calcium in being stimulated by both glucose and high potassium. Biochim Biophys Acta. 1986; 888(3):270-7.
• [28]Demir H, Kanter M, Coskun O, Uz YH, Koc A, Yildiz A. Effect of black cumin (Nigella sativa) on heart rate, some hematological values, and pancreatic beta-cell damage in cadmium-treated rats. Biol Trace Elem Res. 2006; 110(2):151-62.
• [29]Kurata Y, Katsuta O, Doi T, Kawasuso T, Hiratsuka H, Tsuchitani M et al.. Chronic cadmium treatment induces islet B cell injury in ovariectomized cynomolgus monkeys. Jpn J Vet Res. 2003; 50(4):175-83.
• [30]Chapatwala KD, Boykin M, Butts A, Rajanna B. Effect of intraperitoneally injected cadmium on renal and hepatic gluconeogenic enzymes in rats. Drug Chem Toxicol. 1982; 5(3):305-17.
• [31]Han JC, Park SY, Hah BG, Choi GH, Kim YK, Kwon TH et al.. Cadmium induces impaired glucose tolerance in rat by down-regulating GLUT4 expression in adipocytes. Arch Biochem Biophys. 2003; 413(2):213-20.
• [32]Navas-Acien A, Tellez-Plaza M, Guallar E, Muntner P, Silbergeld E, Jaar B et al.. Blood cadmium and lead and chronic kidney disease in US adults: a joint analysis. Am J Epidemiol. 2009; 170(9):1156-64.
• [33]Mi SQ, Yin P, Hu N, Li JH, Chen XR, Chen B et al.. BMI, WC, WHtR, VFI and BFI: which indictor is the most efficient screening index on type 2 diabetes in Chinese community population. BES. 2013; 26(6):485-91.