Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice

Arthritis Research & Therapy

Eiva Bernotiene⁴  Gaby Palmer¹  Dominique Talabot-Ayer¹  Ildiko Szalay-Quinodoz²  Michel L Aubert³  Cem Gabay¹ 

[1] Division of Rheumatology, University Hospital and Department of Pathology, University of Geneva School of Medicine, Geneva, Switzerland

[2] Division of Clinical Pathology, University Hospital, Geneva, Switzerland

[3] Division of Development and Growth, Department of Pediatrics, University of Geneva School of Medicine, Geneva, Switzerland

[4] Department of Immunology, Institute of Experimental and Clinical Medicine at Vilnius University, Vilnius, Lithuania

关键词: leptin;    interleukin-6;    inflammation;    arthritis;    acute phase response;   

Others  :  1101263
DOI  :  10.1186/ar1174

 received in 2003-07-09, accepted in 2004-03-15,  发布年份 2004

【 摘 要 】

The severity of antigen-induced arthritis (AIA) is decreased in leptin-deficient ob/ob mice. However, joint inflammation in AIA depends on the immune response, which is impaired in ob/ob mice. In the present study we investigated the effects of leptin deficiency on zymosan-induced arthritis (ZIA), which is independent of adaptive immunity. Arthritis was induced by injection of zymosan into the knee joint. Joint swelling was similar after 6 and 24 hours in ob/ob and control mice. However, it remained elevated in ob/ob animals on day 3 whereas values normalized in controls. Histology revealed similar articular lesions in all animals on day 3, but on days 14 and 21 arthritis tended to be more severe in ob/ob mice. The acute phase response, reflected by circulating levels of IL-6 and serum amyloid A, was also more pronounced in ob/ob mice, although corticosterone was significantly elevated in these animals. Similar results were obtained in leptin receptor-deficient db/db mice. Thus, in contrast to AIA, ZIA is not impaired in leptin-deficient animals. On the contrary, resolution of acute inflammation appears to be delayed in the absence of leptin or leptin signalling, suggesting that chronic leptin deficiency interferes with adequate control of the inflammatory response in ZIA.

【 授权许可】

   
2004 Bernotiene et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.

【 图 表 】

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