Electrocardiogram frequency change by extracorporeal blood perfusion in a swine ventricular fibrillation model

BioMedical Engineering OnLine

Jung Chan Lee²  Gil Joon Suh³  Hee Chan Kim¹ 

[1] Department of Biomedical Engineering, Seoul National University College of Medicine and Seoul National University Hospital, Yongon-dong 28, Jongro-gu, Seoul 110-744, Republic of Korea

[2] Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Yongon-dong 28, Jongro-gu, Seoul 110-744, Republic of Korea

[3] Department of Emergency Medicine, Seoul National University College of Medicine and Seoul National University Hospital, Yongon-dong 28, Jongro-gu, Seoul 110-744, Republic of Korea

关键词: Ventricular fibrillation (VF);    Extracorporeal cardiopulmonary resuscitation (ECPR);    Frequency analysis;    Electrocardiogram (ECG);   

Others  :  797260
DOI  :  10.1186/1475-925X-12-123

 received in 2013-08-15, accepted in 2013-11-08,  发布年份 2013

【 摘 要 】

Background

Extracorporeal cardiopulmonary resuscitation (ECPR) refers to the application of extracorporeal blood circulation with oxygenation as a resuscitation tool. The objective of this study is to observe the frequency component changes in the electrocardiogram (ECG) by ECPR during prolonged ventricular fibrillation (VF).

Methods

Six swine were prepared as a VF model. Extracorporeal blood circulation with a pulsatile blood pump and oxygenator was set up for the model. ECG signals were measured for 13 min during VF and analyzed using frequency analysis methods. The median frequency (MF), dominant frequency (DF), and amplitude spectrum area (AMSA) were calculated from a spectrogram obtained using short-time Fourier transform (STFT).

Results

MF decreased from 11 Hz at the start to 9 Hz at 2 min after VF and then increased to 11 Hz at 4.5 min after VF. DF started at 7 Hz and increased to 11 Hz within the first min and decreased to 9 Hz at 2 min, then increased to 12 Hz at 4.5 min after VF. Both frequency components decreased gradually from 4.5 min until 10 min after VF. After the oxygenated blood perfusion was initiated, both MF and DF increased remarkably and exceeded 12 and 14 Hz, respectively. Similarly, AMSA decreased gradually for the first 10 min, but increased remarkably and varied beyond 13 mV∙Hz after the oxygenated blood supply started. Remarkable frequency increases in ECG due to the oxygenated blood perfusion during ECPR were observed in the swine VF model.

Conclusions

The ECG frequency analysis during ECPR can give the resuscitation provider important information about the cardiac perfusion status and the appropriateness of the ECPR setup as well as the prediction of defibrillation success.

【 授权许可】

   
2013 Lee et al.; licensee BioMed Central Ltd.

【 图 表 】

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