The expansion of CD4+CD28- T cells in patients with rheumatoid arthritis

Arthritis Research & Therapy

Barbara Gawronska-Szklarz²  Boguslaw Machalinski¹  Marek Masiuk¹  Marek Brzosko³  Iwona Brzosko³  Lidia Ostanek³  Andrzej Pawlik² 

[1]Department of Pathology, Pomeranian University of Medicine, Szczecin, Poland

[2]Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian University of Medicine, Szczecin, Poland

[3]Department of Rheumatology, Pomeranian University of Medicine, Szczecin, Poland

关键词: lymphocytes;    CD4⁺CD28^-;    arthritis;   

Others  :  1101372
DOI  :  10.1186/ar766

 received in 2002-12-20, accepted in 2003-04-08,  发布年份 2003

【 摘 要 】

Clonal expansion of CD4⁺CD28^- T cells is a characteristic finding in patients with rheumatoid arthritis (RA). Expanded CD4⁺ clonotypes are present in the peripheral blood, infiltrate into the joints, and persist for years. CD4⁺CD28^- T cells are oligoclonal lymphocytes that are rare in healthy individuals but are found in high percentages in patients with chronic inflammatory diseases. The size of the peripheral blood CD4⁺CD28^- T-cell compartment was determined in 42 patients with RA and 24 healthy subjects by two-color FACS analysis. The frequency of CD4⁺CD28^- T cells was significantly higher in RA patients than in healthy subjects. Additionally, the number of these cells was significantly higher in patients with extra-articular manifestations and advanced joint destruction than in patients with limited joint manifestations. The results suggest that the frequency of CD4⁺CD28^- T cells may be a marker correlating with extra-articular manifestations and joint involvement.

【 授权许可】

   
2003 Pawlik et al., licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.

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