Local and systemic immunological parameters associated with remission of asthma symptoms in children

Allergy, Asthma & Clinical Immunology

Susan Waserman⁴  Parameswaran Nair⁵  Denis Snider³  Mary Conway⁵  Lata Jayaram⁵  Lynn M McCleary¹  Jerry Dolovich⁵  Frederick E Hargreave⁵  Jean S Marshall² 

[1] Microbiology & Immunology, Dalhousie University, Halifax, NS, Canada

[2] Departments of Pathology, Dalhousie University, Halifax, NS, Canada

[3] Departments of Pathology, McMaster University, Hamilton, ON, Canada

[4] Department of Allergy and Clinical Immunology, McMaster University Medical Centre, 1200 Main Street West, Hamilton, ON, Canada

[5] Departments of Medicine, McMaster University, Hamilton, ON, Canada

关键词: IL-12;    TNF-α;    IL-5;    Eosinophils;    Asthma in children;   

Others  :  792418
DOI  :  10.1186/1710-1492-8-16

 received in 2012-03-16, accepted in 2012-09-18,  发布年份 2012

【 摘 要 】

The immunological and clinical parameters that are associated with asthma remission are poorly understood. The cytokine and local mediator changes associated with the resolution of asthma symptoms were examined in three groups of subjects 12–18 years of age (n = 15 in each group): (a) continuing asthma group (CA) who had persistent symptoms since early childhood, (b) an age, sex and atopic status-matched group who had persistent symptoms in early childhood but in whom these had resolved (RA), and (c) a non-atopic, non-asthmatic control group. Clinical parameters, sputum cell counts, peripheral blood mononuclear cell (PBMC) cytokine production and activation marker expression were determined. All of the CA had methacholine airway hyperresponsiveness compared with only half of the RA subjects. The CA showed elevated numbers of eosinophils and increased ECP and IL-5 in sputum, which were not observed in the RA. PBMC cytokine studies revealed increased production of the type 1 cytokines IL-12, IFN-γ and TNF-α in the CA group compared with the RA group, under a range of activation conditions, however, the production of IL-4 and IL-5 were unchanged. These findings suggest that decreased type 1 cytokine expression as well as decreased eosinophilic inflammation is associated with the resolution of asthma symptoms.

【 授权许可】

   
2012 Waserman et al; licensee BioMed Central Ltd.

【 图 表 】

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