A prospective study in male recipients of kidney transplantation reveals divergent patterns for inhibin B and testosterone secretions

Basic and Clinical Andrology

Safouane M Hamdi¹  Marie Walschaerts¹  Louis Bujan¹  Lionel Rostaing²  Nassim Kamar² 

[1] Université Paul-Sabatier, Toulouse F-31000, France

[2] Département de Néphrologie et Transplantation d’Organes, CHU Toulouse, Toulouse F-31000, France

关键词: Immunosuppression;    Inhibin B;    Testosterone;    Gonadotropins;    Kidney transplantation;    Dialysis;   

Others  :  792833
DOI  :  10.1186/2051-4190-24-11

 received in 2014-04-02, accepted in 2014-06-06,  发布年份 2014

【 摘 要 】

Background

Male patients with chronic kidney disease often exhibit the biological and clinical hallmarks of an abnormal hypothalamo–pituitary–gonadal axis. It is known that dialysis does not reverse this impaired endocrine status; however, the impact of kidney transplantation (KT) is still controversial. The aim of our study was to investigate the levels of serum gonadotropins, testosterone, and inhibin B during dialysis and after KT.

Methods

A longitudinal and prospective single center study was led in an academic setting. Blood hormones levels were assayed by immunoassays in 53 men (mean age: 37 years) receiving dialysis (T₀) and at 6 months post-KT (T₁₈₀). These data were compared with those from 46 fertile semen donors (mean age: 37 years). The main outcome measure was the between-groups differences in hormones levels. A second criterion was the comparison of T₀ and T₁₈₀ hormones levels according to the immunosuppressive regimen.

Results

For patients ongoing dialysis, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) mean levels were high, whereas testosterone and inhibin B mean levels remained normal. After KT, LH levels returned to normal whereas FSH was significantly increased. Testosterone levels remained normal whereas inhibin B levels significantly decreased. We found that the combination tacrolimus plus mycophenolic acid significantly decreased post-KT inhibin B levels. Moreover, we found that pre-graft inhibin-B level was independent of testosterone and could predict low post-operative inhibin B level with a sensitivity of 77% and a specificity of 92%.

Conclusions

Our study suggests that endocrine secretions of Leydig and Sertoli cells are differently impacted by dialysis, KT and immunosuppressive regimen raising new issues to explore.

【 授权许可】

   
2014 HAMDI et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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