Atlas-based white matter analysis in individuals with velo-cardio-facial syndrome (22q11.2 deletion syndrome) and unaffected siblings

Behavioral and Brain Functions

Wendy R Kates¹  Robert J Shprintzen³  Dongliang Wang⁴  Ashwini Kotkar⁵  Christopher S McCarthy⁵  Wanda Fremont⁵  Kevin M Antshel⁵  Ioana L Coman⁵  Petya D Radoeva² 

[1]Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY, 13210, USA

[2]Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA

[3]The Virtual Center for Velo-Cardio-Facial Syndrome, http://www.vcfscenter.com, Manlius, NY, USA

[4]Department of Public Health and Preventive Medicine, SUNY Upstate Medical University, Syracuse, NY, USA

[5]Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA

关键词: LDDMM;    White matter;    DTI;    22q11.2 deletion;    VCFS;   

Others  :  797483
DOI  :  10.1186/1744-9081-8-38

 received in 2012-01-18, accepted in 2012-07-11,  发布年份 2012

【 摘 要 】

Background

Velo-cardio-facial syndrome (VCFS, MIM#192430, 22q11.2 Deletion Syndrome) is a genetic disorder caused by a deletion of about 40 genes at the q11.2 band of one copy of chromosome 22. Individuals with VCFS present with deficits in cognition and social functioning, high risk of psychiatric disorders, volumetric reductions in gray and white matter (WM) and some alterations of the WM microstructure. The goal of the current study was to characterize the WM microstructural differences in individuals with VCFS and unaffected siblings, and the correlation of WM microstructure with neuropsychological performance. We hypothesized that individuals with VCFS would have decreased indices of WM microstructure (fractional anisotropy (FA), axial diffusivity (AD) and radial diffusivity (RD)), particularly in WM tracts to the frontal lobe, and that these measures would be correlated with cognitive functioning.

Methods

Thirty-three individuals with VCFS (21 female) and 16 unaffected siblings (8 female) participated in DTI scanning and neuropsychological testing. We performed an atlas-based analysis, extracted FA, AD, and RD measures for 54 WM tracts (27 in each hemisphere) for each participant, and used MANOVAs to compare individuals with VCFS to siblings. For WM tracts that were statistically significantly different between VCFS and siblings (p_FDR < 0.05), we assessed the correlations between DTI and neuropsychological measures.

Results

In VCFS individuals as compared to unaffected siblings, we found decreased FA in the uncinate fasciculus, and decreased AD in multiple WM tracts (bilateral superior and posterior corona radiata, dorsal cingulum, inferior fronto-occipital fasciculus, superior longitudinal fasciculus, superior cerebellar peduncle, posterior thalamic radiation, and left anterior corona radiata, retrolenticular part of the internal capsule, external capsule, sagittal stratum). We also found significant correlations of AD with measures of executive function, IQ, working memory, and/or social cognition.

Conclusions

Our results suggest that individuals with VCFS display abnormal WM connectivity in a widespread cerebro-anatomical network, involving tracts from/to all cerebral lobes and the cerebellum. Future studies could focus on the WM developmental trajectory in VCFS, the association of WM alterations with psychiatric disorders, and the effects of candidate 22q11.2 genes on WM anomalies.

【 授权许可】

   
2012 Radoeva et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

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