Seminal vesicle metastasis after partial hepatectomy for hepatocellular carcinoma

BMC Cancer

Hong Yan⁴  Wei Zhang⁵  Lifang Shi¹  Wangjun Bu³  Wendong Zhang⁵  Yanhong Li⁵  Minwen Zheng²  Li Gong⁵ 

[1]Department of Radiology, the Second Affiliated Hospital, Xi'an Jiaotong University, 710031 Xi'an, Shaanxi Province, PR China

[2]Department of Radiology, Xijing Hospital, the Fourth Military Medical University, 710032 Xi'an, Shaanxi Province, PR China

[3]Department of General Surgery, the Second Affiliated Hospital, Xi'an Jiaotong University, 710031 Xi'an, Shaanxi Province, PR China

[4]Depatment of Ophthalmology, Tangdu Hospital, the Fourth Military Medical University, 710038 Xi'an, Shaanxi Province, PR China

[5]The Helmholtz Sino-German Laboratory for Cancer Research, Department of Pathology, Tangdu Hospital, the Fourth Military Medical University, 710038 Xi'an, Shaanxi Province, PR China

关键词: clinical pathology;    metastasis;    hepatocellular carcinoma;    seminal vesicle;   

Others  :  1081024
DOI  :  10.1186/1471-2407-11-111

 received in 2010-02-18, accepted in 2011-03-28,  发布年份 2011

【 摘 要 】

Background

Metastasis to the seminal vesicle is extremely rare for hepatocellular carcinoma (HCC). To our knowledge, it has been not reported in literature. The purpose of the present paper was to report a case of metastasis to the seminal vesicle after HCC resection, along with its histological features and immunohistochemical characteristics.

Case Presentation

A 46-year-old Chinese man was admitted to our hospital due to abdominal distension. He had a history of HCC related to hepatitis B virus infection. Moreover, left partial hepatectomy was performed in another hospital 28 months ago, and right partial hepatectomy for HCC recurrence in our hospital 4 months ago. After resection, radiofrequency ablation therapy had been performed. About 27 months after the initial operation, contrast-enhanced computed tomography (CT) of the pelvic cavity revealed a mass with homogeneous enhancement in the seminal vesicle. Transrectal needle biopsy revealed a poorly differentiated adenocarcinoma. Therefore, seminal vesiculectomy was resected. The histological diagnosis of the removed tumor was compatible with the original HCC. Immunohistochemical examination demonstrated that the tumor cells were positive for glypican-3 (GPC3), alpha-fetoprotein (AFP), hepatocyte paraffin-1 (Hep Par 1), cytokeratin 18 (CK 18), and hepatocyte antigen, which confirmed that the seminal vesicle tumor was a metastatic tumor of HCC. However, CT subsequently revealed multiple metastatic foci in the abdominal and pelvic cavities in May 2009 and August 2009, respectively.

Conclusion

The seminal vesicle is an extremely rare metastatic site for HCC, and the prognosis is very poor. A combination of clinical and pathological features is necessary for a correct diagnosis, and primary tumor should be excluded before diagnosing metastatic foci.

【 授权许可】

   
2011 Gong et al; licensee BioMed Central Ltd.

【 图 表 】

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