The relationship between brain-derived neurotrophic factor and cognitive functions in alcohol-dependent patients: a preliminary study

Annals of General Psychiatry

Changwoo Han³  Hwallip Bae⁴  Sung-Doo Won¹  Sungwon Roh²  Dai-Jin Kim⁵ 

[1] Keyo Medical Foundation, Keyo Hospital, Uiwang, Korea

[2] Department of Mental Health Research, Seoul National Hospital, Seoul, Korea

[3] Department of Psychiatry, College of Medicine, Korea University, Ansan Hospital, Ansan, Korea

[4] Department of Psychiatry, Seonam University, Myongji Hospital, Goyang, Korea

[5] Department of Psychiatry, Seoul St. Mary’s Hospital, The Catholic University of Korea College of Medicine, Seoul 137-701, Korea

关键词: Brain-derived neurotrophic factor;    Cognitive function;    Alcohol dependence;   

Others  :  1228875
DOI  :  10.1186/s12991-015-0065-z

 received in 2015-03-04, accepted in 2015-09-08,  发布年份 2015

【 摘 要 】

Background

As a neurotoxic substance, alcohol can induce neurodegenesis in the brain. Alcohol-dependent patients’ cognitive functioning can be affected by chronic alcohol use. In addition, brain-derived neurotrophic factor (BDNF) is known to reflect the status of neuroadaptive changes. The purpose of this study was to investigate the relationship between cognitive functions and BDNF in alcohol-dependent patients.

Methods

The subjects were 39 alcohol-dependent patients. BDNF was measured using an enzyme-linked immunosorbent assay kit. We examined clinical features and administered the Korean version of Alcohol Dependence Scale. We also used the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) to measure cognitive functioning. Then, we determined the relationships between BDNF and various parts of the CERAD.

Results

The performance of alcohol-dependent patients proved stable in most parts of the CERAD. Within the different parts of the CERAD, only Trail Making Test B correlated with BDNF. Trail Making Test specifically assesses executive functions.

Conclusions

BDNF might play an important role in the detection of neurocognitive function among individuals with alcohol dependence.

【 授权许可】

   
2015 Han et al.

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