Effect of prolonged stress on the adrenal hormones of individuals with irritable bowel syndrome

BioPsychoSocial Medicine

Nagisa Sugaya⁵  Shuhei Izawa³  Keisuke Saito²  Kentaro Shirotsuki¹  Shinobu Nomura⁴  Hironori Shimada⁴ 

[1] Faculty of Human Sciences, Musashino University, 3-3-3 Ariake, Koto-ku 135-8181, Tokyo, Japan

[2] Department of Children Education, Tokai University Junior College, 101 Miyamaecho, Aoi-ku 420-8511, Shizuoka, Japan

[3] Health Administration and Psychosocial Factor Research Group, National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki-shi 214-8585, Kanagawa, Japan

[4] Faculty of Human Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa 359-1192, Saitama, Japan

[5] Department of Epidemiology and Public Health, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Kanagawa, Japan

关键词: Prolonged stress;    Saliva;    Dehydroepiandrosterone;    Cortisol;    Irritable bowel syndrome;   

Others  :  1121312
DOI  :  10.1186/s13030-015-0031-7

 received in 2014-10-16, accepted in 2015-01-12,  发布年份 2015

【 摘 要 】

Background

The purpose of this study was to investigate the effect of prolonged stress on the salivary adrenal hormones (cortisol, dehydroepiandrosterone [DHEA], DHEA-sulfate [DHEA-S]) of individuals with irritable bowel syndrome (IBS).

Methods

The participants were female college students, including 10 with IBS and 16 without IBS (control group), who were scheduled for a 2-week teaching practice at a kindergarten. Participants were asked to collect saliva for determining adrenal hormones immediately and 30 min after awakening and before sleep, 2 weeks before the practice, the first week of the practice, the second week of the practice, and a few days after the practice.

Results

Regarding cortisol/DHEA ratio, significantly increased levels were found during the first week of the practice, and a significant interaction between group and time was found; the ratio at 30 min after awakening in the IBS group was higher than that in the control group. For the other adrenal hormone indexes, no significant differences due to the presence of IBS were found.

Conclusions

Individuals with IBS showed an elevated cortisol/DHEA ratio after awakening compared with individuals without IBS, and the elevated ratio peaked under the prolonged stress. The present study suggests that the cortisol effect is dominant in individuals with IBS under prolonged stress.

【 授权许可】

   
2015 Sugaya et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

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