Ozone oxidation of antidepressants in wastewater –Treatment evaluation and characterization of new by-products by LC-QToFMS

Chemistry Central Journal

André Lajeunesse¹  Mireille Blais²  Benoît Barbeau²  Sébastien Sauvé³  Christian Gagnon¹ 

[1] Environment Canada, Wastewater and Effluents Section, Water Science and Technology Directorate, 105 McGill Street, Montreal, Quebec, H2Y 2E7, Canada

[2] École Polytechnique de Montréal, Department of Civil, Geological and Mining Engineering, P.O. Box 6079, Succursale Centre-ville, Montreal, Quebec, H3C 3A7, Canada

[3] Department of Chemistry, Université de Montréal, P.O. Box 6128, Succursale Centre-ville, Montreal, Quebec, H3C 3J7, Canada

关键词: Side-products;    Biosolids;    Sewage treatment plants;    LC-MS/MS;    Ozone;    Antidepressants;   

Others  :  787977
DOI  :  10.1186/1752-153X-7-15

 received in 2012-09-20, accepted in 2013-01-22,  发布年份 2013

【 摘 要 】

Background

The fate of 14 antidepressants along with their respective N-desmethyl metabolites and the anticonvulsive drug carbamazepine was examined in a primary sewage treatment plant (STP) and following advanced treatments with ozone (O₃). The concentrations of each pharmaceutical compound were determined in raw sewage, effluent and sewage sludge samples by LC-MS/MS analysis. The occurrence of antidepressant by-products formed in treated effluent after ozonation was also investigated.

Results

Current primary treatments using physical and chemical processes removed little of the compounds (mean removal efficiency: 19%). Experimental sorption coefficients (K_d) of each studied compounds were also calculated. Sorption of venlafaxine, desmethylvenlafaxine, and carbamazepine on sludge was assumed to be negligible (log K_d ≤ 2), but higher sorption behavior can be expected for sertraline (log K_d ≥ 4). Ozonation treatment with O₃ (5 mg/L) led to a satisfactory mean removal efficiency of 88% of the compounds. Screening of the final ozone-treated effluent samples by high resolution-mass spectrometry (LC-QqToFMS) did confirm the presence of related N-oxide by-products.

Conclusion

Effluent ozonation led to higher mean removal efficiencies than current primary treatment, and therefore represented a promising strategy for the elimination of antidepressants in urban wastewaters. However, the use of O₃ produced by-products with unknown toxicity.

【 授权许可】

   
2013 Lajeunesse et al.; licensee Chemistry Central Ltd.

【 图 表 】

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