DEK over expression as an independent biomarker for poor prognosis in colorectal cancer

BMC Cancer

Lijuan Lin²  Junjie Piao³  Wenbin Gao⁵  Yingshi Piao⁴  Guang Jin⁴  Yue Ma³  Jinzi Li¹  Zhenhua Lin⁴ 

[1] Department of Internal Medicine, Yanbian University Affiliated Hospital, Yanji 133000, China

[2] Department of Medical Imaging, Eastern Liaoning University College of Medicine, Dandong 118002, China

[3] Department of Pathology, Yanbian University College of Medicine, Yanji 133002, China

[4] Cancer Research Center, Yanbian University, Yanji 133002, China

[5] Department of Oncology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116000, China

关键词: Survival analysis;    Immunohistochemistry;    DEK;    Colorectal cancer;   

Others  :  1079624
DOI  :  10.1186/1471-2407-13-366

 received in 2013-01-30, accepted in 2013-06-28,  发布年份 2013

【 摘 要 】

Background

The DEK protein is related to chromatin reconstruction and gene transcription, and plays an important role in cell apoptosis. High expression levels of the human DEK gene have been correlated with numerous human malignancies. This study explores the roles of DEK in tumor progression and as a prognostic determinant of colorectal cancer.

Methods

Colorectal cancer specimens from 109 patients with strict follow-up, and colorectal adenomas from 52 patients were selected for analysis of DEK protein by immunohistochemistry. The correlations between DEK over expression and the clinicopathological features of colorectal cancers were evaluated by Chi-square test and Fisher’s exact tests. The survival rates were calculated by the Kaplan-Meier method, and the relationship between prognostic factors and patient survival was also analyzed by the Cox proportional hazard models.

Results

DEK protein showed a nuclear immunohistochemical staining pattern in colorectal cancers. The strongly positive rate of DEK protein was 48.62% (53/109) in colorectal cancers, which was significantly higher than that in either adjacent normal colon mucosa (9.17%, 10/109) or colorectal adenomas (13.46%, 7/52). DEK over expression in colorectal cancers was positively correlated with tumor size, grade, lymph node metastasis, serosal invasion, late stage, and disease-free survival- and 5-year survival rates. Further analysis showed that patients with late stage colorectal cancer and high DEK expression had worse survival rates than those with low DEK expression. Moreover, multivariate analysis showed high DEK expression, serosal invasion, and late stage are significant independent risk factors for mortality in colorectal cancer.

Conclusions

DEK plays an important role in the progression of colorectal cancers and it is an independent poor prognostic factor of colorectal cancers.

【 授权许可】

   
2013 Lin et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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