期刊论文详细信息
AIDS Research and Therapy | |
HIV post exposure prophylaxis induced bicytopenia: a case report | |
Mathias W Pletz2  Stefan Hagel2  Peter M Keller1  John P Fobiwe3  Benjamin T Schleenvoigt1  | |
[1]Institute for Medical Microbiology, Jena University Hospital, Jena, Germany | |
[2]Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany | |
[3]Center for Infectious Diseases and Infection Control, Jena University Hospital, Erlanger Allee 101, Jena, Thuringia 07740, Germany | |
关键词: Ritonavir; Lopinavir; Emtricitabin; Tenofovir; Thrombocytopenia; Leukopenia; Post exposure prophylaxis; HIV; | |
Others : 789539 DOI : 10.1186/1742-6405-11-11 |
|
received in 2013-11-05, accepted in 2014-02-01, 发布年份 2014 | |
![]() |
【 摘 要 】
Long and short term side effects of antiretroviral drugs are not fully understood yet. Here a case of reversible blood count changes following post exposure prophylaxis with tenofovir/emtricitabin and lopinavir/ritonavir is reported. We propose that antiretroviral drugs used in post exposure prophylaxis may have a significant impact on hematopoiesis.
【 授权许可】
2014 Schleenvoigt et al.; licensee BioMed Central Ltd.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
20140704184506967.pdf | 116KB | ![]() |
【 参考文献 】
- [1]Gemeinsame Erklarung der Deutschen A-G: Post-exposure prophylaxis of HIV infection. German-Austrian recommendations, update September 2007. Dtsch Med Wochenschr 2009, 134(Suppl 1):S16-33.
- [2]Guidelines Version 7.0 October 2013 http://www.eacsociety.org webcite
- [3]Choi SY, Kim I, Kim NJ, Lee SA, Choi YA, Bae JY, Kwon JH, Choe PG, Park WB, Yoon SS, et al.: Hematological manifestations of human immunodeficiency virus infection and the effect of highly active anti-retroviral therapy on cytopenia. Korean J Hematol 2011, 46:253-257.
- [4]Alp E, Bozkurt I, Doganay M: Epidemiological and clinical characteristics of HIV/AIDS patients followed-up in Cappadocia region: 18 years experience. Mikrobiyol Bul 2011, 45:125-136.
- [5]Colebunders R, De Schacht C, Vanwolleghem T, Callens S: Lopinavir/ritonavir- and indinavir-induced thrombocytopenia in a patient with HIV infection. Int J Infect Dis 2004, 8:315-316.
- [6]Fellay J, Boubaker K, Ledergerber B, Bernasconi E, Furrer H, Battegay M, Hirschel B, Vernazza P, Francioli P, Greub G, et al.: Prevalence of adverse events associated with potent antiretroviral treatment: swiss HIV cohort study. Lancet 2001, 358:1322-1327.