Association between lymphocyte and monocyte subsets and cognition in children with HIV

AIDS Research and Therapy

Jintanat Ananworanich⁴  Torsak Bunupuradah⁹  Tanakorn Apornpong⁹  Pope Kosalaraksa¹  Rawiwan Hansudewechakul⁶  Suparat Kanjanavanit²  Chaiwat Ngampiyaskul⁸  Jurai Wongsawat¹²  Wicharn Luesomboon¹³  Nicole Ngo-Giang-Huong¹¹  Tanyathip Jaimulwong⁹  Stephen J Kerr¹⁰  Pim Brouwers⁵  William T Shearer⁷  Thanyawee Puthanakit³ 

[1] Srinagarind Hospital, Khon Kaen University, Khon Kaen, Thailand

[2] Nakornping Hospital, Chiang Mai, Thailand

[3] Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

[4] Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

[5] Division of AIDS Research, National Institute of Mental Health, Bethesda, MD, USA

[6] Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand

[7] Baylor College of Medicine, Houston, USA

[8] Prapokklao Hospital, Chantaburi, Thailand

[9] HIV-NAT, The Thai Red Cross AIDS Research Centre, 104 Rajdumri Road, Pathumwan, Bangkok 10330, Thailand

[10] Kirby Institute of Infection and Immunity in Society, The University of New South Wales, Sydney, Australia

[11] Institut de Recherchepour le Developpement IRD U174, Program for HIV Prevention and Treatment (PHPT), Chiang Mai, Thailand

[12] Bamrasnaradura Infectious Disease Institute, Nonthaburi, Thailand

[13] Queen SavangVadhana Memorial Hospital, Chonburi, Thailand

关键词: Cognition;    Monocytes;    Lymphocytes;    HIV;    Children;   

Others  :  789543
DOI  :  10.1186/1742-6405-11-7

 received in 2013-10-02, accepted in 2014-01-07,  发布年份 2014

【 摘 要 】

Background

This study assesses the relationships between lymphocyte and monocyte subsets and intelligence quotient (IQ) scores in antiretroviral therapy (ART)-naive, HIV-infected Thai children without advanced HIV disease.

Findings

Sixty-seven ART-naive Thai children with CD4 between 15-24% underwent cognitive testing by Weschler intelligence scale and had 13 cell subsets performed by flow cytometry including naive, memory and activated subsets of CD4+ and CD8+ T cells, activated and perivascular monocytes and B cells. Regression modelling with log₁₀ cell count and cell percentage transformation was performed.

Median age (IQR) was 9 (7–10) years, 33% were male, CDC stages N:A:B were 1:67:31%, median CD4% and count (IQR) were 21 (18–24)%, 597 (424–801) cells/mm³ and HIV RNA (IQR) was 4.6 (4.1-4.9) log₁₀ copies/ml. Most (82%) lived at home, 45% had a biological parent as their primary caregiver, and 26 (49%) had low family income. The mean (SD) scores were 75 (13) for full scale IQ (FIQ), 73 (12) for verbal IQ (VIQ) and 80 (14) for performance IQ (PIQ). Adjusted multivariate regression analysis showed significant negative associations between B cell counts and FIQ, VIQ and PIQ (p < 0.01 for all); similar associations were found for B cell percentages (p < 0.05 for all).

Conclusions

High B cell counts and percentages were strongly associated with poorer FIQ, VIQ and PIQ scores. Prospective, long-term assessment of cell subsets and determination of relevant B cell subpopulations could help further elucidate associations between lymphocyte subsets and neurocognitive development.

【 授权许可】

   
2014 Ananworanich et al.; licensee BioMed Central Ltd.

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