Conservation of major and minor jelly-roll capsid proteins in Polinton (Maverick) transposons suggests that they are bona fide viruses

Biology Direct

Eugene V Koonin³  Dennis H Bamford¹  Mart Krupovic² 

[1]Department of Biosciences and Institute of Biotechnology, University of Helsinki, Viikki Biocenter 2, P.O. Box 56 (Viikinkaari 5)FIN-00014 Helsinki, Finland

[2]Department of Microbiology, Institut Pasteur, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Paris 75015, France

[3]National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA

关键词: Virus evolution;    Capsid proteins;    Double jelly-roll fold;    Transposable elements;    Mavericks;    Polintons;   

Others  :  792950
DOI  :  10.1186/1745-6150-9-6

 received in 2014-03-10, accepted in 2014-04-24,  发布年份 2014

【 摘 要 】

Reviewers

This article was reviewed by Lakshminarayan M. Iyer and I. King Jordan. For complete reviews, see the Reviewers’ Reports section.

Polintons (also known as Mavericks) and Tlr elements of Tetrahymena thermophila represent two families of large DNA transposons widespread in eukaryotes. Here, we show that both Polintons and Tlr elements encode two key virion proteins, the major capsid protein with the double jelly-roll fold and the minor capsid protein, known as the penton, with the single jelly-roll topology. This observation along with the previously noted conservation of the genes for viral genome packaging ATPase and adenovirus-like protease strongly suggests that Polintons and Tlr elements combine features of bona fide viruses and transposons. We propose the name ‘Polintoviruses’ to denote these putative viruses that could have played a central role in the evolution of several groups of DNA viruses of eukaryotes.

【 授权许可】

   
2014 Krupovic et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Fig.2.

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