Acta Veterinaria Scandinavica | |
Effect of propofol on oxidative stress status in erythrocytes from dogs under general anaesthesia | |
Jae Yeon Lee1  Myung Cheol Kim1  | |
[1] Department of Veterinary Surgery, College of Veterinary Medicine, Research Institute of Veterinary Medicine, Chungnam National University, Daejeon, 305-764, Korea | |
关键词: Propofol; Oxidative stress; Dogs; Antioxidant effects; Anaesthesia; | |
Others : 789424 DOI : 10.1186/1751-0147-54-76 |
|
received in 2012-08-01, accepted in 2012-12-16, 发布年份 2012 | |
【 摘 要 】
Background
Alterations of the normal redox balance might be attributed to increase of plasma free-radical concentration and a disruption of the antioxidant defense system. One of the adverse effects of general anaesthetics is the exogen sources of reactive oxygen radicals that are responsible for several diseases. The purposes of the current study were to evaluate the effect of propofol on oxidative stress and to compare the differences between propofol induction only and induction plus continuous infusion on antioxidant status in dogs.
Findings
Beagle dogs were evaluated in the present study. The dogs were assigned randomly to receive three treatments in a crossover model. The three treatments were: group 1 (n = 9), 2% isoflurane; group 2 (n = 9), anaesthesia induced with an intravenous (IV) bolus dose of 6 mg/kg propofol and maintained with 1.5–2% isoflurane; group 3 (n = 9), total IV anaesthesia (induction with 6 mg/kg propofol, infusion with 0.6 mg/kg/min propofol). The results of this study show that dogs exposed to isoflurane had decreased antioxidant enzymes activities, whereas dogs injected with propofol had increased antioxidant enzymes activities.
Conclusions
The results of this study showed that an infusion dose of propofol has antioxidant effects in dogs. These effects may be beneficial to patients in whom free radicals play a role in oxidative stress, such as those with ischemia. Further studies are needed to evaluate whether these antioxidant effects of the anaesthetic are of clinical value.
【 授权许可】
2012 Lee and Kim; licensee BioMed Central Ltd.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
20140704175927946.pdf | 376KB | download | |
Figure 1. | 32KB | Image | download |
【 图 表 】
Figure 1.
【 参考文献 】
- [1]Sies H: Oxidative stress: oxidants and antioxidants. Exp Physiol 1997, 82:291-295.
- [2]Kato R, Foëx P: Myocardial protection by anesthetic agents against ischemia-reperfusion injury: an update for anesthesiologists. Can J Anaesth 2002, 49:777-791.
- [3]Aarts L, van der Hee R, Dekker I, de Jong J, Langemeijer H, Bast A: The widely used anesthetic agent propofol can replace alpha-tocopherol as an antioxidant. FEBS Lett 1995, 2:83-85.
- [4]Michels C, Raes M, Toussaint O, Remacle J: Importance of Se-glutathione peroxidase, catalase, and Cu/Zn SOD for cell survival against oxidative stress. Free Radic Biol Med 1994, 17:235-248.
- [5]Lee JY: Oxidative stress due to anesthesia and surgical trauma and comparison of the effects of propofol and thiopental in dogs. J Vet Med Sci 2012, 74:663-665.
- [6]Kotani N, Hashimoto H, Sessler DI, Yasuda T, Ebina T, Muraoka M, Matsuki A: Expression of genes for proinflammatory cytokines in alveolar macrophages during propofol and isoflurane anesthesia. Anesth Analg 1999, 89:1250-1256.
- [7]De La Cruz JP, Zanca A, Carmona JA, de la Cuesta FS: The effect of propofol on oxidative stress in platelets from surgical patients. Anesth Analg 1999, 89:1050-1055.