Prognostic significance of peripheral monocyte count in patients with extranodal natural killer/T-cell lymphoma

BMC Cancer

Jia-Jia Huang¹  Ya-Jun Li¹  Yi Xia¹  Yu Wang¹  Wen-Xiao Wei¹  Ying-Jie Zhu¹  Tong-Yu Lin¹  Hui-Qiang Huang¹  Wen-Qi Jiang¹  Zhi-Ming Li¹ 

[1] Department of Medical Oncology, Sun Yat-sen University Cancer Center, 651 Dong Feng RD East, Guangzhou 510060, China

关键词: Tumor microenvironment;    Prognosis;    Extranodal natural killer/T-cell lymphoma;    Absolute monocyte count;   

Others  :  1079769
DOI  :  10.1186/1471-2407-13-222

 received in 2012-12-13, accepted in 2013-04-25,  发布年份 2013

【 摘 要 】

Background

Extranodal natural killer/T-cell lymphoma (ENKL) has heterogeneous clinical manifestations and prognosis. This study aims to evaluate the prognostic impact of absolute monocyte count (AMC) in ENKL, and provide some immunologically relevant information for better risk stratification in patients with ENKL.

Methods

Retrospective data from 163 patients newly diagnosed with ENKL were analyzed. The absolute monocyte count (AMC) at diagnosis was analyzed as continuous and dichotomized variables. Independent prognostic factors of survival were determined by Cox regression analysis.

Results

The AMC at diagnosis were related to overall survival (OS) and progression-free survival (PFS) in patients with ENKL. Multivariate analysis identified AMC as independent prognostic factors of survival, independent of International Prognostic Index (IPI) and Korean prognostic index (KPI). The prognostic index incorporating AMC and absolute lymphocyte count (ALC), another surrogate factor of immune status, could be used to stratify all 163 patients with ENKL into different prognostic groups. For patients who received chemotherapy followed by radiotherapy (102 cases), the three AMC/ALC index categories identified patients with significantly different survivals. When superimposed on IPI or KPI categories, the AMC/ALC index was better able to identify high-risk patients in the low-risk IPI or KPI category.

Conclusion

The baseline peripheral monocyte count is shown to be an effective prognostic indicator of survival in ENKL patients. The prognostic index related to tumor microenvironment might be helpful to identify high-risk patients with ENKL.

【 授权许可】

   
2013 Huang et al.; licensee BioMed Central Ltd.

【 图 表 】

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