Cardiac autonomic impairment and chronotropic incompetence in fibromyalgia

Arthritis Research & Therapy

Bruno Gualano²  Eloísa Bonfá¹  Fernanda Rodrigues Lima¹  Ana Lúcia de Sá Pinto¹  Ana Luisa Calich¹  Luiz Augusto Perandini¹  Thalita Dassouki¹  Guilherme Gianini Artioli²  Hamilton Roschel²  Roberta Potenza da Cunha Ribeiro¹ 

[1]Division of Rheumatology, School of Medicine, University of Sao Paulo, Brazil. Av. Dr. Arnaldo, 455, Cerqueira César, Brazil

[2]School of Physical Education and Sport, University of Sao Paulo, Brazil. Av. Prof. Mello Moraes, 65, Butantã, Brazil

关键词: autonomic dysfunction;    cardiovascular risk;    abnormal heart-rate response;   

Others  :  1098411
DOI  :  10.1186/ar3519

 received in 2011-05-19, accepted in 2011-11-18,  发布年份 2011

【 摘 要 】

Introduction

We aimed to gather knowledge on the cardiac autonomic modulation in patients with fibromyalgia (FM) in response to exercise and to investigate whether this population suffers from chronotropic incompetence (CI).

Methods

Fourteen women with FM (age: 46 ± 3 years; body mass index (BMI): 26.6 ± 1.4 kg/m²) and 14 gender-, BMI- (25.4 ± 1.3 kg/m²), and age-matched (age: 41 ± 4 years) healthy individuals (CTRL) took part in this cross-sectional study. A treadmill cardiorespiratory test was performed and heart-rate (HR) response during exercise was evaluated by the chronotropic reserve. HR recovery (deltaHRR) was defined as the difference between HR at peak exercise and at both first (deltaHRR1) and second (deltaHRR2) minutes after the exercise test.

Results

FM patients presented lower maximal oxygen consumption (VO₂ max) when compared with healthy subjects (22 ± 1 versus CTRL: 32 ± 2 mL/kg/minute, respectively; P < 0.001). Additionally, FM patients presented lower chronotropic reserve (72.5 ± 5 versus CTRL: 106.1 ± 6, P < 0.001), deltaHRR1 (24.5 ± 3 versus CTRL: 32.6 ± 2, P = 0.059) and deltaHRR2 (34.3 ± 4 versus CTRL: 50.8 ± 3, P = 0.002) than their healthy peers. The prevalence of CI was 57.1% among patients with FM.

Conclusions

Patients with FM who undertook a graded exercise test may present CI and delayed HR recovery, both being indicative of cardiac autonomic impairment and higher risk of cardiovascular events and mortality.

【 授权许可】

   
2011 da Cunha Ribeiro et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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