Zymomonas mobilis: a novel platform for future biorefineries

Biotechnology for Biofuels

Ming Xiong He³  Bo Wu¹  Han Qin¹  Zhi Yong Ruan²  Fu Rong Tan¹  Jing Li Wang¹  Zong Xia Shui¹  Li Chun Dai¹  Qi Li Zhu¹  Ke Pan¹  Xiao Yu Tang¹  Wen Guo Wang¹  Qi Chun Hu³ 

[1] Biogas Institute of Ministry of Agriculture, Biomass Energy Technology Research Centre, Section 4-13, Renming Nanlu, Chengdu 610041, P. R. China

[2] Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences, Beijing 100081, P. R. China

[3] Key Laboratory of Development and Application of Rural Renewable Energy, Ministry of Agriculture, Chengdu 610041, P. R. China

关键词: building block chemical;    biofuel;    biorefinery;    platform;    Zymomonas mobilis;   

Others  :  1084886
DOI  :  10.1186/1754-6834-7-101

 received in 2014-02-17, accepted in 2014-06-20,  发布年份 2014

【 摘 要 】

Biosynthesis of liquid fuels and biomass-based building block chemicals from microorganisms have been regarded as a competitive alternative route to traditional. Zymomonas mobilis possesses a number of desirable characteristics for its special Entner-Doudoroff pathway, which makes it an ideal platform for both metabolic engineering and commercial-scale production of desirable bio-products as the same as Escherichia coli and Saccharomyces cerevisiae based on consideration of future biomass biorefinery. Z. mobilis has been studied extensively on both fundamental and applied level, which will provide a basis for industrial biotechnology in the future. Furthermore, metabolic engineering of Z. mobilis for enhancing bio-ethanol production from biomass resources has been significantly promoted by different methods (i.e. mutagenesis, adaptive laboratory evolution, specific gene knock-out, and metabolic engineering). In addition, the feasibility of representative metabolites, i.e. sorbitol, bionic acid, levan, succinic acid, isobutanol, and isobutanol produced by Z. mobilis and the strategies for strain improvements are also discussed or highlighted in this paper. Moreover, this review will present some guidelines for future developments in the bio-based chemical production using Z. mobilis as a novel industrial platform for future biofineries.

【 授权许可】

   
2014 He et al.; licensee BioMed Central Ltd.

【 图 表 】

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