BMC Bioinformatics | |
4273π: Bioinformatics education on low cost ARM hardware | |
Daniel Barker1  David EK Ferrier5  Peter WH Holland2  John BO Mitchell4  Heleen Plaisier1  Michael G Ritchie1  Steven D Smart3  | |
[1] Sir Harold Mitchell Building, School of Biology, University of St Andrews, St Andrews, Fife KY16 9TH, UK | |
[2] Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK | |
[3] School of Biology, Bute Building, University of St Andrews, St Andrews, Fife KY16 9TS, UK | |
[4] Biomedical Sciences Research Complex and EaStCHEM School of Chemistry, Purdie Building, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, UK | |
[5] Scottish Oceans Institute, School of Biology, University of St Andrews, East Sands, St Andrews, Fife KY16 8LB, UK | |
关键词: Linux; Raspberry Pi; Teaching material; Bioinformatics education; | |
Others : 1087792 DOI : 10.1186/1471-2105-14-243 |
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received in 2013-04-24, accepted in 2013-07-09, 发布年份 2013 | |
【 摘 要 】
Background
Teaching bioinformatics at universities is complicated by typical computer classroom settings. As well as running software locally and online, students should gain experience of systems administration. For a future career in biology or bioinformatics, the installation of software is a useful skill. We propose that this may be taught by running the course on GNU/Linux running on inexpensive Raspberry Pi computer hardware, for which students may be granted full administrator access.
Results
We release 4273π, an operating system image for Raspberry Pi based on Raspbian Linux. This includes minor customisations for classroom use and includes our Open Access bioinformatics course, 4273π Bioinformatics for Biologists. This is based on the final-year undergraduate module BL4273, run on Raspberry Pi computers at the University of St Andrews, Semester 1, academic year 2012–2013.
Conclusions
4273π is a means to teach bioinformatics, including systems administration tasks, to undergraduates at low cost.
【 授权许可】
2013 Barker et al.; licensee BioMed Central Ltd.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
20150117043600875.pdf | 1454KB | download | |
Figure 1. | 67KB | Image | download |
【 图 表 】
Figure 1.
【 参考文献 】
- [1]Altschul SF, Madden TL, Schäffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ: Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 1997, 25:3389-3402.
- [2]NCBI BLAST home. http://blast.ncbi.nlm.nih.gov/Blast.cgi webcite
- [3]GNU operating system. http://www.gnu.org webcite
- [4]Field D, Tiwari B, Booth T, Houten S, Swan D, Bertrand N, Thurston M: Open software for biologists: from famine to feast. Nat Biotechnol 2006, 24:801-803.
- [5]Bassi S, Gonzalez VC: DNALinux virtual desktop edition. Nature Precedings 2007. http://dx.doi.org/10.1038/npre.2007.670.1 webcite
- [6]Bio-Linux 7 USB memory sticks. http://nebc.nerc.ac.uk/tools/bio-linux/live-usbkey webcite
- [7]Yu G, Wang LG, Meng XH, He QY: LXtoo: an integrated live Linux distribution for the bioinformatics community. BMC Res Notes 2012, 5:360. BioMed Central Full Text
- [8]Raspberry Pi: An ARM GNU/Linux box for $25. http://www.raspberrypi.org webcite
- [9]BBC News: The Raspberry Pi computer goes on general sale. http://www.bbc.co.uk/news/technology-17190918 webcite
- [10]Element14 Community: Raspberry Pi. http://www.element14.com/community/groups/raspberry-pi webcite
- [11]RS Components: Raspberry Pi. http://uk.rs-online.com/web/generalDisplay.html?id=raspberrypi webcite
- [12]Roberts J: Is the Raspberry Pi the future of computing? techradar.pro, from Linux Format Issue 156. 2012. http://www.techradar.com/news/computing/pc/is-the-raspberry-pi-the-future-of-computing-1078276 webcite
- [13]ARM: The architecture for the digital world. http://www.arm.com webcite
- [14]Latif L: ARM sees its 32-bit chips being deployed in future servers: not everything needs 64-bit addressing. The Inquirer. 2013. http://www.theinquirer.net/inquirer/news/2259386/arm-sees-its-32bit-chips-being-deployed-in-future-servers webcite
- [15]2000 Nickels: A Cray for $35. http://2000nickels.com/blog/2012/11/19/a-cray-for-35-dollars webcite
- [16]Raspberry Pi: Operating system distributions. http://www.raspberrypi.org/phpBB3/viewforum.php?f=18 webcite
- [17]Raspbian. http://www.raspbian.org webcite
- [18]Debian. http://www.debian.org webcite
- [19]Möller S, Krabbenhöft HN, Tille A, Paleino D, Williams A, Wolstencroft K, Goble C, Holland R, Belhachemi D, Plessy C: Community-driven computational biology with Debian Linux. BMC Bioinformatics 2010, 11(Suppl 12):S5. BioMed Central Full Text
- [20]O’Boyle NM: Noel O’Blog: Chemistrify your Raspberry Pi Part III. http://baoilleach.blogspot.co.uk/2013/01/chemistrify-your-raspberry-pi-part-iii_19.html webcite
- [21]Raspberry Pi: Wayland preview. http://www.raspberrypi.org/archives/4053 webcite
- [22]University of St Andrews: Undergraduate course catalogue 2012–2013. http://www.st-andrews.ac.uk/coursecatalogue/ug/2012-2013 webcite
- [23]Bradnam K, Korf I: Unix and Perl to the rescue! a field guide for the life sciences (and other data-rich pursuits). Cambridge: Cambridge University Press; 2012.
- [24]Raspberry Pi: Downloads. http://www.raspberrypi.org/downloads webcite
- [25]4273π. http://eggg.st-andrews.ac.uk/4273pi webcite
- [26]Korf I: Gene finding in novel genomes. BMC Bioinformatics 2004, 5:59. BioMed Central Full Text
- [27]Birney E, Clamp M, Durbin R: GeneWise and Genomewise. Genome Res 2004, 14:988-995.
- [28]EMBL-EBI: GeneWise input form. http://www.ebi.ac.uk/Tools/psa/genewise webcite
- [29]Marygold SJ, Leyland PC, Seal RL, Goodman JL, Thurmond J, Strelets VB, Wilson RJ, the FlyBase Consortium: FlyBase: improvements to the bibliography. Nucleic Acids Res 2013, 41:D751-D757.
- [30]Gardiner A, Barker D, Butlin RK, Jordan WC, Ritchie MG: Drosophila chemoreceptor gene evolution: selection, specialization and genome size. Mol Ecol 2008, 17:1648-1657.
- [31]Chambers R: Vestiges of the natural history of creation. London: John Churchill; 1844.
- [32]Yang Z: PAML 4: Phylogenetic analysis by maximum likelihood. Mol Biol Evol 2007, 24:1586-1591.
- [33]Keane TM, Creevey CJ, Pentony MP, Naughton TJ, Mclnerney JO: Assessment of methods for amino acid matrix selection and their use on empirical data shows that ad hoc assumptions for choice of matrix are not justified. BMC Evol Biol 2006, 6:29. BioMed Central Full Text
- [34]Maddison WP, Maddison DR: Mesquite: a modular system for evolutionary analysis. Version 2.75. 2011. http://mesquiteproject.org webcite
- [35]Guindon S, Dufayard JF, Lefort V, Anisimova M, Hordijk W, Gascuel O: New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Syst Biol 2010, 59:307-321.
- [36]EcoEd digital library. http://ecoed.esa.org webcite
- [37]EvoEd digital library: DRD partners and people. http://evoed.evolutionsociety.org/index.php?P=DRD_People webcite
- [38]XE Currency converter. http://www.xe.com/currencyconverter webcite