Lung cancer in HIV patients and their parents: A Danish cohort study

BMC Cancer

Niels Obel⁵  Jan Gerstoft⁵  Court Pedersen²  Gitte Pedersen⁴  Carsten S Larsen³  Gitte Kronborg¹  Frederik N Engsig⁵ 

[1]Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre Hospital, Kettegårds Allé 30, 2650 Hvidovre, Denmark

[2]Department of Infectious Diseases, Odense University Hospital, Sønderbouldevard 65, 5000 Odense C, Denmark

[3]Department of Infectious Diseases, Aarhus University Hospital, Brendstrupgårdsvej, 8200 Aarhus N, Denmark

[4]Department of Infectious Diseases, Aalborg University Hospital, 9000 Aalborg, Denmark

[5]Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Kbh Ø, Denmark

关键词: immunosuppression;    parents;    population controls;    matched cohort;    lung cancer incidence;    HIV;   

Others  :  1080863
DOI  :  10.1186/1471-2407-11-272

 received in 2011-01-31, accepted in 2011-06-25,  发布年份 2011

【 摘 要 】

Background

HIV patients are known to be at increased risk of lung cancer but the risk factors behind this are unclear.

Methods

We estimated the cumulative incidence and relative risk of lung cancer in 1) a population of all Danish HIV patients identified from the Danish HIV Cohort Study (n = 5,053) and a cohort of population controls matched on age and gender (n = 50,530) (study period; 1995 - 2009) and 2) their parents (study period; 1969 - 2009). Mortality and relative risk of death after a diagnosis of lung cancer was estimated in both populations.

Results

29 (0.6%) HIV patients vs. 183 (0.4%) population controls were diagnosed with lung cancer in the observation period. HIV patients had an increased risk of lung cancer (adjusted incidence rate ratio (IRR); 2.38 (95% CI; 1.61 - 3.53)). The IRR was considerably increased in HIV patients who were smokers or former smokers (adjusted IRR; 4.06 (95% CI; 2.66 - 6.21)), male HIV patients with heterosexual route of infection (adjusted IRR; 4.19 (2.20 - 7.96)) and HIV patients with immunosuppression (adjusted IRR; 3.25 (2.01 - 5.24)). Both fathers and mothers of HIV patients had an increased risk of lung cancer (adjusted IRR for fathers; 1.31 (95% CI: 1.09 - 1.58), adjusted IRR for mothers 1.35 (95% CI: 1.07 - 1.70)). Mortality after lung cancer diagnose was increased in HIV patients (adjusted mortality rate ratio 2.33 (95%CI; 1.51 - 3.61), but not in the parents. All HIV patients diagnosed with lung cancer were smokers or former smokers.

Conclusion

The risk was especially increased in HIV patients who were smokers or former smokers, heterosexually infected men or immunosuppressed. HIV appears to be a marker of behavioural or family related risk factors that affect the incidence of lung cancer in HIV patients.

【 授权许可】

   
2011 Engsig et al; licensee BioMed Central Ltd.

【 图 表 】

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