Why are psychiatric imaging methods clinically unreliable? Conclusions and practical guidelines for authors, editors and reviewers

Behavioral and Brain Functions

Stefan Borgwardt²  Joaquim Radua¹  Andrea Mechelli¹  Paolo Fusar-Poli¹ 

[1] Department of Psychosis Studies, Institute of Psychiatry, King’s College London, De Crespigny Park, London, SE5 8AF, UK

[2] Department of Psychiatry, University of Basel, Petersgraben 4, Basel, CH 4031, Switzerland

关键词: Meta-analyses;    Voxel-based morphometry;    Region-of-interest;    Magnetic resonance imaging;    Neuroimaging;    Guidelines;   

Others  :  794021
DOI  :  10.1186/1744-9081-8-46

 received in 2012-05-08, accepted in 2012-08-24,  发布年份 2012

【 摘 要 】

No reliable anatomical or functional alterations have been confirmed in psychiatric neuroimaging; however it can become reliable with translational impact on clinical practice when considering crucial methodological issues. We provide guidelines to authors, editors and reviewers in the implementation/evaluation of neuroimaging studies to bend neuroimaging to be more than basic neuroscience.

【 授权许可】

   
2012 Borgwardt et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Johnstone EC, Crow TJ, Frith CD, Husband J, Kreel L: Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet 1976, 7992:924-926.
• [2]Fusar-Poli P, Broome MR: Conceptual issues in psychiatric neuroimaging. Curr Opin Psychiatry 2006, 19:608-612.
• [3]Fusar-Poli P, Broome M, Barale F, Stanghellini G: Why is psychiatric imaging clinically unreliable? Epistemological perspectives in clinical neuroscience. Psychother Psychosom 2009, 78:320-321.
• [4]Fusar-Poli P, Allen P, McGuire P: Neuroimaging studies of the early stages of psychosis: a critical review. Eur Psychiatry 2008, 23:237-244.
• [5]Fusar-Poli P, Bhattacharyya S, Allen P, Crippa JA, Borgwardt S, Martin-Santos R, Seal M, O’Carroll C, Atakan Z, Zuardi AW, McGuire P: Effect of image analysis software on neurofunctional activation during processing of emotional human faces. J Clin Neurosci 2010, 17:311-314.
• [6]Ioannidis JP: Excess significance bias in the literature on brain volume abnormalities. Arch Gen Psychiatry 2011, 68:773-780.
• [7]Radua J, van den Heuvel OA, Surguladze S, Mataix-Cols D: Meta-analytical comparison of voxel-based morphometry studies in obsessivecompulsive disorder vs. other anxiety disorders. Arch Gen Psychiatry 2010, 67:701-711.
• [8]Radua J, Mataix-Cols D, Phillips ML, El-Hage W, Kronhaus DM, Cardoner N, Surguladze S: A new meta-analytic method for neuroimaging studies that combines reported peak coordinates and statistical parametric maps. Eur Psychiatry 2011. published online June 7