Coordinative interaction of microcrystalline chitosan with oxovanadium (IV) ions in aqueous solution

Chemistry Central Journal

Marta E Lichawska³  Kazimiera H Bodek²  Julia Jezierska¹  Aleksander Kufelnicki³ 

[1] Faculty of Chemistry, University of Wrocław, Wrocław, 50-383, Poland

[2] Chair of Applied Pharmacy, Faculty of Pharmacy, Medical University of Łódź, Łódź, 90-151, Poland

[3] Department of Physical and Biocoordination Chemistry, Faculty of Pharmacy, Medical University of Łódź, Łódź, 90-151, Poland

关键词: Equilibria in aqueous solution;    Metal-polymer complexes;    Vanadium (IV);    Microcrystalline chitosan;    Biomaterial;   

Others  :  1083747
DOI  :  10.1186/s13065-014-0050-7

 received in 2014-05-08, accepted in 2014-07-31,  发布年份 2014

【 摘 要 】

Background

Chitosan, a non-toxic, biodegradable and biocompatible polysaccharide has attained great interest in pharmaceutical applications, as versatile drug delivery agent. Chitosan has been already shown to serve as vehicle for sustained drug release by chitosan-vanadium(IV) complex from a chitosan gel matrix. Therefore, chitosan gel proved to retain vanadium and preserve its insulin-mimetic efficacy. Nevertheless, there is a lack of reports concerning complexing equilibria in aqueous solution, in particular when using the more advantageous microcrystalline form of chitosan (MCCh). Microcrystalline chitosan shows a number of valuable features as compared with unmodified chitosan.

Results

Experimental studies on complexing interaction between a special form of biomaterial - microcrystalline chitosan as ligand, L = MCCh, of two exemplary degrees of deacetylation DD (lower 79.8%; higher 97.7%) with M = oxovanadium (IV) ions have been carried out potentiometrically at four ligand-to-metal concentration ratios (2:1, 5:1, 8:1, 10:1). Among the five hydrolysis equilibria of VO²⁺ reported up to now in the literature, under the conditions of the present work i.e. aqueous solutions of ionic strength I = 0.1 (KNO₃) and temperature 25.0 ± 0.1°C, the predominating one was (VO)₂(OH)₂  ²⁺ formation: log β_20–2 = −7.01(2). Analysis of potentiometric results permitted to note that degree of deacetylation does not essentially influence the coordination mode of the complexes formed. In the case of both the two DD values, as well as for all the ligand-to-metal ratios, formation of hydroxyl deprotonated MLH₋₁ and ML₂H₋₂ moieties has been confirmed potentiometrically (log β_11–1 = −0.68(2) for DD = 79.8% and −0.68(2) for DD = 97.7%, log β_12–2 = −7.64(6) for DD = 79.8% and −5.38(7) for DD = 97.7%).

Conclusion

Microcrystalline chitosan coordinates the vanadyl ions by the hydroxyl groups. Interaction of MCCh with VO²⁺ ions in aqueous solution occurs within pH 5–7. Amounts of alkali excessive towards -NH₂ are needed to deprotonate the OH groups. Deprotonation occurring at the chitosan hydroxyl groups permits a “pendant” or “bridge” model of coordination with VO(IV). Lack of complexation via deprotonation of amine groups, typical for simple cations and the molybdenum anion, has been indicated also by FTIR spectroscopy and EPR.

【 授权许可】

   
2014 Lichawska et al.; licensee Chemistry Central Ltd.

【 图 表 】

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