Time-dependent integrity during storage of natural surface water samples for the trace analysis of pharmaceutical products, feminizing hormones and pesticides

Chemistry Central Journal

Sébastien Sauvé¹  Michèle Prévost²  Cyril De Potter¹  Khadija Aboulfadl² 

[1]Département de chimie, Université de Montréal, Montréal, QC, Canada

[2]Chaire CRSNG en Eau Potable, Département des génies civil, géologique et des mines, École Polytechnique de Montréal, Canada

Others  :  788500
DOI  :  10.1186/1752-153X-4-10

 received in 2009-12-10, accepted in 2010-04-19,  发布年份 2010

【 摘 要 】

Monitoring and analysis of trace contaminants such as pharmaceuticals and pesticides require the preservation of the samples before they can be quantified using the appropriate analytical methods. Our objective is to determine the sample shelf life to insure proper quantification of ultratrace contaminants. To this end, we tested the stability of a variety of pharmaceutical products including caffeine, natural steroids, and selected pesticides under refrigerated storage conditions. The analysis was performed using multi-residue methods using an on-line solid-phase extraction combined with liquid chromatography tandem mass spectrometry (SPE-LC-MS/MS) in the selected reaction monitoring mode. After 21 days of storage, no significant difference in the recoveries was observed compared to day 0 for pharmaceutical products, while for pesticides, significant losses occurred for DIA and simazine after 10 days (14% and 17% reduction respectively) and a statistically significant decrease in the recovery was noted for cyanazine (78% disappearance). However, the estrogen and progestogen steroids were unstable during storage. The disappearance rates obtained after 21 days of storage vary from 63 to 72% for the feminizing hormones. Overall, pharmaceuticals and pesticides seem to be stable for refrigerated storage for up to about 10 days (except cyanazine) and steroidal hormones can be quite sensitive to degradation and should not be stored for more than a few days.

【 授权许可】

   
2010 Aboulfadl et al

【 图 表 】

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