Synthetic circuit designs for earth terraformation

Biology Direct

Ricard V. Solé²  Raúl Montañez¹  Salva Duran-Nebreda¹ 

[1] Institut de Biologia Evolutiva, (CSIC-Universitat Pompeu Fabra), Passeig Marítim de la Barceloneta 37, Barcelona, 08003, Spain

[2] Santa Fe Institute, 1399 Hyde Park road, Santa Fe 87501, NM, USA

关键词: Mutualism;    Catastrophic shifts;    Climate change;    Ecological engineering;    Synthetic biology;   

Others  :  1225807
DOI  :  10.1186/s13062-015-0064-7

 received in 2015-03-16, accepted in 2015-06-24,  发布年份 2015

【 摘 要 】

Background

Mounting evidence indicates that our planet might experience runaway effects associated to rising temperatures and ecosystem overexploitation, leading to catastrophic shifts on short time scales. Remediation scenarios capable of counterbalancing these effects involve geoengineering, sustainable practices and carbon sequestration, among others. None of these scenarios seems powerful enough to achieve the desired restoration of safe boundaries.

Presentation of the hypothesis

We hypothesize that synthetic organisms with the appropriate engineering design could be used to safely prevent declines in some stressed ecosystems and help improving carbon sequestration. Such schemes would include engineering mutualistic dependencies preventing undesired evolutionary processes. We hypothesize that some particular design principles introduce unescapable constraints to the engineered organisms that act as effective firewalls.

Testing the hypothesis

Testing this designed organisms can be achieved by using controlled bioreactor models, with single and heterogeneous populations, and accurate computational models including different scales (from genetic constructs and metabolic pathways to population dynamics).

Implications of the hypothesis

Our hypothesis heads towards a future anthropogenic action that should effectively act as Terraforming processes. It also implies a major challenge in the existing biosafety policies, since we suggest release of modified organisms as potentially necessary strategy for success.

Reviewers

This article was reviewed by This article was reviewed by Eugene V. Koonin, Tom Ellis (nominated by Purificación Lopez-Garcia) and Eörs Szathmary.

【 授权许可】

   
2015 Sole et al.

【 图 表 】

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