No association between serum cholesterol and death by suicide in patients with schizophrenia, bipolar affective disorder, or major depressive disorder

Behavioral and Brain Functions

Subin Park²  Ki Kyoung Yi¹  Riji Na¹  Ahyoung Lim¹  Jin Pyo Hong¹ 

[1] Department of Psychiatry, Asan Medical Center, Ulsan University College of Medicine, 388-1 Pungnap-2dong Songpa-gu, Seoul 138-736, South Korea

[2] Department of Psychiatry, Seoul National University Hospital, Seoul, Korea

关键词: Depressive disorder;    Bipolar affective disorder;    Schizophrenia;    Laboratory markers;    Suicide;   

Others  :  792062
DOI  :  10.1186/1744-9081-9-45

 received in 2013-06-19, accepted in 2013-11-23,  发布年份 2013

【 摘 要 】

Background

Previous research on serum total cholesterol and suicidality has yielded conflicting results. Several studies have reported a link between low serum total cholesterol and suicidality, whereas others have failed to replicate these findings, particularly in patients with major affective disorders. These discordant findings may reflect the fact that studies often do not distinguish between patients with bipolar and unipolar depression; moreover, definitions and classification schemes for suicide attempts in the literature vary widely.

Methods

Subjects were patients with one of the three major psychiatric disorders commonly associated with suicide: schizophrenia, bipolar affective disorder, and major depressive disorder (MDD). We compared serum lipid levels in patients who died by suicide (82 schizophrenia, 23 bipolar affective disorder, and 67 MDD) and non-suicide controls (200 schizophrenia, 49 bipolar affective disorder, and 175 MDD).

Results

Serum lipid profiles did not differ between patients who died by suicide and control patients in any diagnostic group.

Conclusions

Our results do not support the use of biological indicators such as serum total cholesterol to predict suicide risk among patients with a major psychiatric disorder.

【 授权许可】

   
2013 Park et al.; licensee BioMed Central Ltd.

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