Serum IL-6 and IL-10 concentrations in bitches with pyometra undergoing ovariohysterectomy

Acta Veterinaria Scandinavica

Roman Dąbrowski¹  Josep Pastor²  Marek Szczubiał¹  Tomasz Piech¹  Mariola Bochniarz¹  Władysław Wawron¹  Asta Tvarijonaviciute³ 

[1] Department and Clinic of Animal Reproduction, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 30 Gleboka St., Lublin, 20-612, Poland

[2] Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Universidad Autónoma de Barcelona, Barcelona, Spain

[3] Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Universidad de Murcia, Murcia, Spain

关键词: Post surgery monitoring;    Ovariohysterectomy;    Pyometra;    Bitches;    Cytokines;   

Others  :  1227519
DOI  :  10.1186/s13028-015-0153-8

 received in 2015-06-03, accepted in 2015-09-21,  发布年份 2015

【 摘 要 】

Background

Pyometra is a serious bacterial infection of the uterus affecting female dogs and manifests as an accumulation of pus in the uterine lumen. The aim of the study was to assess changes in serum interleukin (IL)-6 and IL-10 concentrations in bitches with pyometra undergoing ovariohysterectomy.

Findings

Blood samples were collected from healthy bitches (controls) and bitches with pyometra before surgery, and 3 and 10 days after ovariohysterectomy. Before surgery, bitches with pyometra had significantly higher serum concentrations of IL-6 and IL-10 than the controls. After surgery, the serum concentration of IL-6 and IL-10 decreased significantly. In healthy dogs, the concentration of IL-6 and IL-10 showed a significant increase 3 days after surgery followed by a decrease on day 10.

Conclusion

An increase in serum concentrations of IL-6 and IL-10 was present before surgery in bitches with pyometra and 3 days after ovariohysterectomy in healthy controls. Concentrations decreased after ovariohysterectomy and/or proper healing, suggesting that these cytokines can be useful for assessment of the postoperative period in bitches.

【 授权许可】

   
2015 Dąbrowski et al.

【 图 表 】

Fig.1.

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